U12 minor spliceosomal RNA

U12 minor spliceosomal RNA
Predicted secondary structure and sequence conservation of U12
Identifiers
Symbol	U12
Rfam	RF00007
Other data
RNA type	Gene; snRNA; splicing
Domain(s)	Eukaryota
GO	0000371 0045131 0005693
SO	0000399

U12 minor spliceosomal RNA is formed from U12 small nuclear (snRNA), together with U4atac/U6atac, U5, and U11 snRNAs and associated proteins, forms a spliceosome that cleaves a divergent class of low-abundance pre-mRNA introns. Although the U12 sequence is very divergent from that of U2, the two are functionally analogous. The predicted secondary structure of U12 RNA is published, but the alternative single hairpin in the 3' end shown here seems to better match the alignment of divergent Drosophila melanogaster and Arabidopsis thaliana sequences. The sequences U12 introns that are spliced out are collected in a biological database called the U12 intron database.