UNC13A

UNC13A
Identifiers
Aliases	UNC13A, Munc13-1, unc-13 homolog A (C. elegans), unc-13 homolog A
External IDs	MGI: 3051532 HomoloGene: 11279 GeneCards: UNC13A
Gene ontology Molecular function • protein N-terminus binding • syntaxin-1 binding • metal ion binding • diacylglycerol binding • calmodulin binding Cellular component • cytoplasm • membrane • neuromuscular junction • plasma membrane • synapse • axon • cell junction • neuron projection • presynaptic membrane • presynapse • terminal bouton • calyx of Held • presynaptic active zone Biological process • cell differentiation • intracellular signal transduction • synaptic vesicle docking • synaptic transmission, glutamatergic • regulation of short-term neuronal synaptic plasticity • positive regulation of neurotransmitter secretion • amyloid-beta metabolic process • neuromuscular junction development • positive regulation of dendrite extension • regulation of synaptic transmission, glutamatergic • innervation • synaptic vesicle maturation • neurotransmitter secretion • exocytosis • chemical synaptic transmission • synaptic vesicle exocytosis • synaptic vesicle priming • positive regulation of synaptic plasticity • positive regulation of glutamate receptor signaling pathway • regulation of amyloid precursor protein catabolic process • presynaptic dense core vesicle exocytosis Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	23025	382018
Ensembl	ENSG00000130477	ENSMUSG00000034799
UniProt	Q9UPW8	Q4KUS2
RefSeq (mRNA)	NM_001080421	NM_001029873
RefSeq (protein)	NP_001073890	NP_001025044
Location (UCSC)	Chr 19: 17.6 – 17.69 Mb	Chr 8: 71.62 – 71.67 Mb
PubMed search

23025

382018

ENSG00000130477

ENSMUSG00000034799

Q9UPW8

Q4KUS2

NM_001080421

NM_001029873

NP_001073890

NP_001025044

Unc-13 homolog A (C. elegans) is a protein that in humans is encoded by the UNC13A gene.

This gene encodes a member of the UNC13 family. UNC13A plays a role in vesicle maturation during exocytosis as a target of the diacylglycerol second messenger pathway. It is involved in neurotransmitter release by acting in synaptic vesicle priming prior to vesicle fusion and participates in the activity-dependent refilling of readily releasable vesicle pool. In Drosophila melanogaster, the protein has been shown to define the vesicle release site by regulating the coupling distance between synaptic vesicles and calcium channels in cooperation with another isoform, UNC13B. It is particularly important in most glutamatergic-mediated synapses but not GABA-mediated synapses. It plays a role in dendrite formation by melanocytes and in secretory granule priming in insulin secretion.

...
Wikipedia