UNC13B

UNC13B
Identifiers
Aliases	UNC13B, MUNC13, UNC13, Unc13h2, unc-13 homolog B (C. elegans)
External IDs	MGI: 1342278 HomoloGene: 31376 GeneCards: UNC13B
Genetically Related Diseases
Parkinson's disease
Gene ontology Molecular function • metal ion binding • protein binding • calmodulin binding • Rab GTPase binding • diacylglycerol binding • GTP-dependent protein binding Cellular component • cytosol • neuromuscular junction • plasma membrane • synapse • cell junction • cytoplasm • Golgi apparatus • membrane • early phagosome • terminal bouton • calyx of Held • presynaptic active zone • ribbon synapse • presynapse Biological process • exocytosis • intracellular signal transduction • synaptic vesicle docking • positive regulation of synaptic vesicle priming • synaptic transmission, glutamatergic • regulation of short-term neuronal synaptic plasticity • positive regulation of inhibitory postsynaptic potential • glutamate secretion • neuromuscular junction development • synaptic vesicle priming • innervation • neurotransmitter secretion • chemical synaptic transmission • synaptic vesicle exocytosis • negative regulation of synaptic plasticity • positive regulation of apoptotic process • positive regulation of protein secretion • cellular response to glucose stimulus • phagosome maturation • positive regulation of defense response to bacterium • presynaptic dense core vesicle exocytosis Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	10497	22249
Ensembl	ENSG00000198722	ENSMUSG00000028456
UniProt	O14795	Q9Z1N9
RefSeq (mRNA)	NM_006377 NM_001330653	NM_001081413 NM_021468 NM_001310758
RefSeq (protein)	NP_001317582 NP_006368	NP_001074882.1 NP_001297687.1 NP_067443.2 NP_001074882 NP_001297687 NP_067443
Location (UCSC)	Chr 9: 35.16 – 35.41 Mb	Chr 4: 43.06 – 43.26 Mb
PubMed search

10497

22249

ENSG00000198722

ENSMUSG00000028456

O14795

Q9Z1N9

NM_006377
NM_001330653

NM_001081413
NM_021468
NM_001310758

NP_001317582
NP_006368

NP_067443

Protein unc-13 homolog B is a protein that in humans is encoded by the UNC13B gene.

This gene is expressed in the kidney cortical epithelial cells and is upregulated by hyperglycemia. The encoded protein shares a high level of similarity to the rat homolog, and contains 3 C2 domains and a diacylglycerol-binding C1 domain. Hyperglycemia increases the levels of diacylglycerol, which has been shown to induce apoptosis in cells transfected with this gene and thus contribute to the renal cell complications of hyperglycemia. Studies in other species also indicate a role for this protein in the priming step of synaptic vesicle exocytosis.

UNC13B has been shown to interact with:

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Wikipedia