UPF3B

UPF3B
Available structures PDB Human UniProt search: PDBe RCSB List of PDB id codes 1UW4, 2XB2
Identifiers
Aliases	UPF3B, HMRX62, MRXS14, RENT3B, UPF3X, Upf3p-X, UPF3BP1, UPF3BP2, UPF3BP3, UPF3 regulator of nonsense transcripts homolog B (yeast), UPF3 regulator of nonsense transcripts homolog B, regulator of nonsense mediated mRNA decay
External IDs	MGI: 1915384 HomoloGene: 11307 GeneCards: UPF3B
Gene ontology Molecular function • protein binding • mRNA binding • nucleocytoplasmic transporter activity • nucleic acid binding • RNA binding Cellular component • exon-exon junction complex • nucleoplasm • microtubule organizing center • nucleolus • nucleus • cytoplasm • cytosol Biological process • mRNA splicing, via spliceosome • termination of RNA polymerase II transcription • mRNA transport • mRNA export from nucleus • positive regulation of translation • nuclear-transcribed mRNA catabolic process, nonsense-mediated decay • mRNA 3'-end processing • RNA export from nucleus • transport Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	65109	68134
Ensembl	ENSG00000125351	ENSMUSG00000036572
UniProt	Q9BZI7	n/a
RefSeq (mRNA)	NM_023010 NM_080632	NM_026573
RefSeq (protein)	NP_075386 NP_542199	n/a
Location (UCSC)	Chr X: 119.81 – 119.85 Mb	Chr X: 37.09 – 37.11 Mb
PubMed search

1UW4, 2XB2

65109

68134

ENSG00000125351

ENSMUSG00000036572

Q9BZI7

n/a

NM_023010
NM_080632

NM_026573

NP_075386
NP_542199

n/a

Regulator of nonsense transcripts 3B is a protein that in humans is encoded by the UPF3B gene.

This gene encodes a protein that is part of a post-splicing multiprotein complex involved in both mRNA nuclear export and mRNA surveillance. The encoded protein is one of two functional homologs to yeast Upf3p. mRNA surveillance detects exported mRNAs with truncated open reading frames and initiates nonsense-mediated mRNA decay (NMD). When translation ends upstream from the last exon-exon junction, this triggers NMD to degrade mRNAs containing premature stop codons. This protein binds to the mRNA and remains bound after nuclear export, acting as a nucleocytoplasmic shuttling protein. It forms with Y14 a complex that binds specifically 20 nt upstream of exon-exon junctions. This gene is located on the long arm of chromosome X. Two splice variants encoding different isoforms have been found for this gene.

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