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Leverett Saltonstall
Republican
Incumbent U.S. Senator Henry Cabot Lodge, Jr. resigned February 3, 1944 to return to active duty in the U.S. Army during World War II. Republican Sinclair Weeks was appointed February 8, 1944 to continue the term until an election was held. A special election was held on November 7, 1944 with Republican Massachusetts Governor Leverett Saltonstall defeating his challengers. He didn't take office until January 4, 1945, when his term as Governor ended.