Uteroglobin

SCGB1A1
Identifiers
Aliases	SCGB1A1, CC10, CC16, CCPBP, CCSP, UGB, UP-1, UP1, secretoglobin family 1A member 1
External IDs	OMIM: 192020 MGI: 98919 HomoloGene: 2518 GeneCards: SCGB1A1
Genetically Related Diseases
chronic obstructive pulmonary disease
Gene ontology Molecular function • polychlorinated biphenyl binding • phospholipase A2 inhibitor activity • protein binding Cellular component • cytoplasm • rough endoplasmic reticulum • nuclear envelope • intracellular • secretory granule • extracellular region • endoplasmic reticulum • extracellular exosome • extracellular space Biological process • response to cytokine • negative regulation of interferon-gamma production • negative regulation of interleukin-5 production • negative regulation of catalytic activity • response to xenobiotic stimulus • negative regulation of interleukin-4 production • regulation of mRNA stability • female pregnancy • response to fibroblast growth factor • response to glucocorticoid • negative regulation of transcription from RNA polymerase II promoter • response to ozone • response to organic substance • negative regulation of interleukin-13 production • response to lipopolysaccharide • negative regulation of T cell proliferation • regulation of inflammatory response • response to silicon dioxide • embryo implantation • response to drug • signal transduction Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	7356	22287
Ensembl	ENSG00000149021	ENSMUSG00000024653
UniProt	P11684	Q06318
RefSeq (mRNA)	NM_003357	NM_011681
RefSeq (protein)	NP_003348	NP_035811.1 NP_035811
Location (UCSC)	Chr 11: 62.41 – 62.42 Mb	Chr 19: 9.08 – 9.09 Mb
PubMed search

7356

22287

ENSG00000149021

ENSMUSG00000024653

P11684

Q06318

NM_003357

NM_011681

NP_003348

NP_035811.1
NP_035811

Uteroglobin, also known as secretoglobin family 1A member 1 (SCGB1A1), is a protein that in humans is encoded by the SCGB1A1 gene.

SCGB1A1 is the founding member of the secretoglobin family of small, secreted, disulfide-bridged dimeric proteins found only in mammals. This antiparallel disulfide linked homodimeric protein is multifunctional and found in various tissues in various names such as: Uteroglobin (UG, UGB), Uteroglobin-like Antigen (UGL), Blastokinin, club cell secretory protein (CCSP), Clara cell 16 kD protein (17 in rat/mice), club Cell-Specific 10 kD Protein (CC10), human protein 1, urine protein 1 (UP-1), polychlorinated biphenyl-binding protein (PCB-BP), human club Cell Phospholipid-Binding Protein (hCCPBP), Secretoglobin 1A member 1 (SCGB1A1).

This protein is specifically expressed in club cells in the lungs.

Real physiological role is not known. Putative functions are:

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Wikipedia