VAV2

VAV2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2DLZ, 2DM1, 2LNW, 2LNX, 4ROJ
Identifiers
Aliases	VAV2, VAV-2, vav guanine nucleotide exchange factor 2
External IDs	MGI: 102718 HomoloGene: 2530 GeneCards: VAV2
Genetically Related Diseases
multiple sclerosis
Gene ontology Molecular function • guanyl-nucleotide exchange factor activity • epidermal growth factor receptor binding • metal ion binding • protein binding • Rho guanyl-nucleotide exchange factor activity Cellular component • cytoplasm • cytosol • plasma membrane Biological process • regulation of cell size • intracellular signal transduction • Fc-gamma receptor signaling pathway involved in phagocytosis • regulation of GTPase activity • ephrin receptor signaling pathway • positive regulation of phosphatidylinositol 3-kinase activity • platelet activation • Fc-epsilon receptor signaling pathway • vascular endothelial growth factor receptor signaling pathway • cell projection assembly • angiogenesis • positive regulation of apoptotic process • regulation of gene expression • regulation of blood coagulation • regulation of Rho protein signal transduction • regulation of small GTPase mediated signal transduction • cell migration • signal transduction • lamellipodium assembly • small GTPase mediated signal transduction • positive regulation of GTPase activity Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	7410	22325
Ensembl	ENSG00000160293	ENSMUSG00000009621
UniProt	P52735	Q60992
RefSeq (mRNA)	NM_001134398 NM_003371	NM_009500
RefSeq (protein)	NP_001127870 NP_003362	NP_033526.1 NP_033526
Location (UCSC)	Chr 9: 133.76 – 133.99 Mb	Chr 2: 27.26 – 27.43 Mb
PubMed search

2DLZ, 2DM1, 2LNW, 2LNX, 4ROJ

7410

22325

ENSG00000160293

ENSMUSG00000009621

P52735

Q60992

NM_001134398
NM_003371

NM_009500

NP_001127870
NP_003362

NP_033526.1
NP_033526

Guanine nucleotide exchange factor VAV2 is a protein that in humans is encoded by the VAV2 gene.

VAV2 is the second member of the VAV oncogene family. Unlike VAV1, which is expressed exclusively in hematopoietic cells, VAV2 transcripts were found in most tissues.

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