Vardandukht was an Armenian noblewoman, whom through marriage became a Queen consort who lived in the 4th century. She is known as the wife of Arsaces III (Arshak III) who was the last serving Roman Client King of Arsacid Armenia. Arsaces III reigned from 378 until his death in 387.
Vardandukht was the daughter of the great sparapet (chief general) Manuel Mamikonian of the pro-Roman, powerful and wealthy Mamikonian family by an unnamed mother. She was born and raised in Armenia.
The previous Roman client Armenian King Papas (Pap) was assassinated in 374. As Arsaces III and his younger brother, Vologases, were both too young to rule and succeed their father, the Roman emperor Valens had sent their paternal first cousin Varasdates (Varazdat) to occupy the Armenian throne. Their cousin who was a young man highly reputed for his mental and physical gifts had lived in Rome for an unknown period of time. Varasdates began to rule under the regency of Mushegh I Mamikonian.
In 378 with the failed reign of Varasdates and the murder of Mushegh Mamikonian, who was Vardandukht’s paternal uncle, her father, Manuel filled his late brother’s position of sparapet. Manuel, furious at the Armenian King, with a military force drove out Varasdates from Armenia back to Rome. Manuel raised Arsaces III and his brother Vologases to the throne as co-kings of Armenia, under the nominal regency of their mother Zarmandukht.
To end the political anarchy in the country as Manuel being now the powerful regent-in-charge of Armenia, Manuel married Arsaces III to Vardandukht and he married Vologases to the daughter of Sahak from the Bagratuni Dynasty. Through marriage, Vardandukht became a relation to the ruling Arsacid dynasty of Armenia and a powerful, influential woman in Armenian society. Not much is known on her relationship with Arsaces III and she bore him no children.