Vasoactive intestinal peptide receptor
| vasoactive intestinal peptide receptor 1 | |
|---|---|
| Identifiers | |
| Symbol | VIPR1 |
| Alt. symbols | RDC1, HVR1, VAPC1 |
| Entrez | 7433 |
| HUGO | 12694 |
| OMIM | 192321 |
| RefSeq | NM_004624 |
| UniProt | P32241 |
| Other data | |
| Locus | Chr. 3 p22 |
| vasoactive intestinal peptide receptor 2 | |
|---|---|
| Identifiers | |
| Symbol | VIPR2 |
| Alt. symbols | VPAC2 |
| Entrez | 7434 |
| HUGO | 12695 |
| OMIM | 601970 |
| RefSeq | NM_003382 |
| UniProt | P41587 |
| Other data | |
| Locus | Chr. 7 q36.3 |
| adenylate cyclase activating polypeptide 1 (pituitary) receptor type I | |
|---|---|
| Identifiers | |
| Symbol | ADCYAP1R1 |
| Alt. symbols | PACAPR |
| Entrez | 117 |
| HUGO | 242 |
| OMIM | 102981 |
| RefSeq | NM_001118 |
| UniProt | P41586 |
| Other data | |
| Locus | Chr. 7 p14 |
There are two known receptors for the vasoactive intestinal peptide (VIP) termed VPAC1 and VPAC2. These receptors bind both VIP and pituitary adenylate cyclase-activating polypeptide (PACAP) to some degree. Both receptors are members of the 7 transmembrane G protein-coupled receptor family.
VPAC1 is distributed widely in the CNS, liver, lung, intestine and T-lymphocytes.
VPAC2 is found in the CNS, pancreas, skeletal muscle, heart, kidney, adipose tissue, testis, and stomach.
Vasoactive intestinal peptide (VIP) and pituitary adenylate cyclase-activating peptide (PACAP) receptors are activated by the endogenous peptides VIP, PACAP-38, PACAP-27, peptide histidine isoleucineamide (PHI), peptide histidine methionineamide (PHM) and peptide histidine valine (PHV). “PACAP type II receptors” (VPAC1 and VPAC2 receptors) display comparable affinity for PACAP and VIP, whereas PACAP-27 and PACAP-38 are >100 fold more potent than VIP as agonists of most isoforms of the PAC1 receptor.
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