Vinculin

VCL

Available structures

Ortholog search: PDBe RCSB

List of PDB id codes
1RKC, 1RKE, 1SYQ, 1TR2, 2GWW, 2IBF, 3H2U, 3H2V, 3MYI, 3TJ5, 3TJ6, 3VF0, 4DJ9, 4EHP, 1YDI, 2HSQ, 3RF3, 3S90, 4LN2, 4LNP, 4PR9, 3JBK

Identifiers

Aliases

VCL, CMD1W, CMH15, HEL114, MV, Mvinculin

External IDs

OMIM: 193065 MGI: 98927 HomoloGene: 7594 GeneCards: VCL

Gene ontology
Molecular function	• beta-catenin binding • dystroglycan binding • structural molecule activity • protein binding • actin binding • alpha-catenin binding • ubiquitin protein ligase binding • cadherin binding
Cellular component	• cytoplasm • extracellular vesicle • cytosol • outer dense plaque of desmosome • cell • membrane • cell-cell junction • focal adhesion • cell-substrate junction • adherens junction • plasma membrane • inner dense plaque of desmosome • cell-cell adherens junction • protein complex • terminal web • extracellular region • cell junction • brush border • actin cytoskeleton • zonula adherens • membrane raft • fascia adherens • costamere • cytoskeleton • extracellular exosome • podosome • secretory granule lumen • specific granule lumen • ficolin-1-rich granule lumen
Biological process	• movement of cell or subcellular component • regulation of cell migration • muscle contraction • adherens junction assembly • epithelial cell-cell adhesion • platelet degranulation • morphogenesis of an epithelium • cell adhesion • negative regulation of cell migration • protein localization to cell surface • axon extension • cell-matrix adhesion • platelet aggregation • apical junction assembly • lamellipodium assembly • neutrophil degranulation
Sources:Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

Entrez


7414


22330

Ensembl


ENSG00000035403


ENSMUSG00000021823

UniProt


P18206


Q64727

RefSeq (mRNA)


NM_003373 NM_014000


NM_009502

RefSeq (protein)


NP_003364 NP_054706


NP_033528.3 NP_033528

Location (UCSC)

Chr 10: 74 – 74.12 Mb

Chr 14: 20.93 – 21.03 Mb

PubMed search

VBS

human vinculin head (1-258) in complex with talin's vinculin binding site 3 (residues 1944-1969)

Identifiers

Symbol

VBS

Available protein structures:
Pfam	structures
PDB	RCSB PDB; PDBe; PDBj
PDBsum	structure summary

Available protein structures:
Pfam	structures
PDB	RCSB PDB; PDBe; PDBj
PDBsum	structure summary

1RKC, 1RKE, 1SYQ, 1TR2, 2GWW, 2IBF, 3H2U, 3H2V, 3MYI, 3TJ5, 3TJ6, 3VF0, 4DJ9, 4EHP, 1YDI, 2HSQ, 3RF3, 3S90, 4LN2, 4LNP, 4PR9, 3JBK

7414

22330

ENSG00000035403

...
Wikipedia