WAP5

WFDC2
Identifiers
Aliases	WFDC2, EDDM4, HE4, WAP5, dJ461P17.6, WAP four-disulfide core domain 2
External IDs	MGI: 1914951 HomoloGene: 4450 GeneCards: WFDC2
Gene location (Human) Chr. Chromosome 20 (human) Band No data available Start 45,469,706 bp End 45,481,532 bp
Gene location (Mouse) Chr. Chromosome 2 (mouse) Band No data available Start 164,562,413 bp End 164,568,510 bp
RNA expression pattern More reference expression data
Gene ontology Molecular function • aspartic-type endopeptidase inhibitor activity • peptidase inhibitor activity • endopeptidase inhibitor activity • serine-type endopeptidase inhibitor activity • cysteine-type endopeptidase inhibitor activity Cellular component • extracellular region • extracellular exosome • extracellular space Biological process • negative regulation of peptidase activity • proteolysis • spermatogenesis • negative regulation of endopeptidase activity Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	10406	67701
Ensembl	ENSG00000101443	ENSMUSG00000017723
UniProt	Q14508	Q9DAU7
RefSeq (mRNA)	NM_006103 NM_080733 NM_080734 NM_080735 NM_080736	NM_026323
RefSeq (protein)	NP_006094	NP_080599
Location (UCSC)	Chr 20: 45.47 – 45.48 Mb	Chr 20: 164.56 – 164.57 Mb
PubMed search

10406

67701

ENSG00000101443

ENSMUSG00000017723

Q14508

Q9DAU7

NM_006103
NM_080733
NM_080734
NM_080735
NM_080736

NM_026323

NP_006094

NP_080599

WAP four-disulfide core domain protein 2 - also known as Human Epididymis Protein 4 (HE4) - is a protein that in humans is encoded by the WFDC2 gene.

HE4 is a tumor marker of ovarian cancer, with 80% sensitivity at a cut-off of 150 pmol/L.

This gene encodes a protein that is a member of the WFDC domain family. The WFDC domain, or WAP Signature motif, contains eight cysteines forming four disulfide bonds at the core of the protein, and functions as a protease inhibitor in many family members. This gene is expressed in pulmonary epithelial cells, and was also found to be expressed in some ovarian cancers. The encoded protein is a small secretory protein, which may be involved in sperm maturation.

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Wikipedia