WAY-100,635

WAY-100,635

Identifiers
IUPAC name N-[2-[4-(2-methoxyphenyl)-1-piperazinyl]ethyl]- N-(2-pyridyl)cyclohexanecarboxamide
CAS Number	146714-97-8 Y
PubChem CID	5684
IUPHAR/BPS	80
ChemSpider	5482 N
ChEMBL	CHEMBL31354 N
Chemical and physical data
Formula	C25H34N4O2
Molar mass	422.56 g/mol
3D model (Jmol)	Interactive image
SMILES COC1=CC=CC=C1N2CCN(CC2)CCN(C3=CC=CC=N3)C(=O)C4CCCCC4
InChI InChI=1S/C25H34N4O2/c1-31-23-12-6-5-11-22(23)28-18-15-27(16-19-28)17-20-29(24-13-7-8-14-26-24)25(30)21-9-3-2-4-10-21/h5-8,11-14,21H,2-4,9-10,15-20H2,1H3 N Key:SBPRIAGPYFYCRT-UHFFFAOYSA-N N
NY (what is this?)

WAY-100,635 is a piperazine drug and research chemical widely used in scientific studies. It was originally believed to act as a selective 5-HT_1A receptor antagonist, but subsequent research showed that it also acts as potent full agonist at the D₄ receptor. It is sometimes referred to as a silent antagonist at the former receptor. It is closely related to WAY-100,135.

In light of its only recently discovered dopaminergic activity, conclusions drawn from studies that employed WAY-100635 as a selective 5-HT_1A antagonist may need to be re-evaluated.

In human PET studies WAY-100,635 shows high binding in the cerebral cortex, hippocampus, raphe nucleus and amygdaloid nucleus, while lower in thalamus and basal ganglia. One study described a single case with relatively high binding in the cerebellum.

In relating its binding to subject variables one Swedish study found WAY-100,635 binding in raphe brain region correlating with self-transcendence and spiritual acceptance personality traits. WAY-100,635 binding has also been assessed in connection with clinical depression, where there has been disagreement about the presence and direction of the 5-HT_1A receptor binding. In healthy subjects WAY-100,635 binding has been found to decline with age, — though not all studies have found this relationship.