WWOX

WWOX
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1WMV
Identifiers
Aliases	WWOX, D16S432E, FOR, FRA16D, HHCMA56, PRO0128, SCAR12, SDR41C1, WOX1, EIEE28, WW domain containing oxidoreductase
External IDs	MGI: 1931237 HomoloGene: 56334 GeneCards: WWOX
Genetically Related Diseases
bipolar disorder, anorexia nervosa, Obesity
Gene ontology Molecular function • RNA polymerase II transcription coactivator activity • protein dimerization activity • protein binding • cofactor binding • coenzyme binding • enzyme binding • oxidoreductase activity Cellular component • cytoplasm • cytosol • Golgi apparatus • plasma membrane • microvillus • RNA polymerase II transcription factor complex • mitochondrion • nucleus Biological process • cellular response to transforming growth factor beta stimulus • steroid metabolic process • extrinsic apoptotic signaling pathway • negative regulation of Wnt signaling pathway • skeletal system morphogenesis • Wnt signaling pathway • positive regulation of extrinsic apoptotic signaling pathway in absence of ligand • osteoblast differentiation • intrinsic apoptotic signaling pathway by p53 class mediator • positive regulation of extrinsic apoptotic signaling pathway • oxidation-reduction process • positive regulation of transcription from RNA polymerase II promoter • apoptotic process • negative regulation of transcription from RNA polymerase II promoter Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	51741	80707
Ensembl	ENSG00000186153	ENSMUSG00000004637
UniProt	Q9NZC7	Q91WL8
RefSeq (mRNA)	NM_001291997 NM_016373 NM_018560 NM_130788 NM_130790 NM_130791 NM_130792 NM_130844	NM_019573
RefSeq (protein)	NP_001278926 NP_057457 NP_570607	NP_062519.2 NP_062519
Location (UCSC)	Chr 16: 78.1 – 79.21 Mb	Chr 8: 114.44 – 115.35 Mb
PubMed search

1WMV

51741

80707

ENSG00000186153

ENSMUSG00000004637

Q9NZC7

Q91WL8

NM_130791
NM_130792
NM_130844

NM_019573

NP_001278926
NP_057457
NP_570607

NP_062519.2
NP_062519

WW domain-containing oxidoreductase is an enzyme that in humans is encoded by the WWOX gene.

WW domain-containing proteins are found in all eukaryotes and play an important role in the regulation of a wide variety of cellular functions such as protein degradation, transcription, and RNA splicing. This gene encodes a protein which contains 2 WW domains and a short-chain dehydrogenase/reductase domain (SRD). The highest normal expression of this gene is detected in hormonally regulated tissues such as testis, ovary, and prostate. This expression pattern and the presence of an SRD domain suggest a role for this gene in steroid metabolism. The encoded protein is more than 90% identical to the mouse protein, which is an essential mediator of tumor necrosis factor-alpha-induced apoptosis, suggesting a similar, important role in apoptosis for the human protein. In addition, there is evidence that this gene behaves as a suppressor of tumor growth. Alternative splicing of this gene generates transcript variants that encode different isoforms.

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Wikipedia