Wayne Harold Osborne (October 11, 1912 – March 13, 1987) was a pitcher in Major League Baseball who played for the Pittsburgh Pirates (1935) and Boston Bees (1936). Osborne batted left-handed and threw right-handed. He was born in Watsonville, California, and went straight from high school onto the Portland Beavers in 1931.

In a two-season career, Osborne posted a 1–1 record with nine strikeouts and a 5.91 ERA in 21-1/3 innings pitched.

Osborne died in Vancouver, Washington, at the age of 74.

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