William D. M. Paton
| William D.M. Paton | |
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William D.M. Paton in 1984
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| Born | 5 May 1917 |
| Died | 17 October 1993 (aged 76) |
| Occupation | British pharmacologist |
| Awards | Gairdner Foundation International Award (1959) |
Professor Sir William Drummond Macdonald Paton FRS (5 May 1917 – 17 October 1993) was a British pharmacologist.
Paton was born in Hendon and educated at Repton School and New College, Oxford, where he was awarded a BA in animal physiology. In 1939 he entered University College Hospital (UCH) to study clinical medicine and was appointed house physician to the medical unit.
Unfit for military service he took the post of pathologist in a tuberculosis sanatorium, later moving to the National Institute for Medical Research, then in Hampstead, London. He worked at NIMR for 8 years on the pharmacology of acetylcholine and its benefits in the control of hypertension. For this work he and his colleague Eleanor Zaimis were amongst the recipients of the first Gairdner Foundation International Awards in 1959.
In 1952 he returned to UCH as reader in applied pharmacology, and spent the next two years studying submarine physiology, developing the blend of oxygen, helium and nitrogen (Tri-mix) which enables divers to work at deeper depths.
He was elected a Fellow of the Royal Society in 1956. His nomination citation read: " Distinguished for his researches on histamine and methonium compounds. With MacIntosh he showed that many simple organic bases are histamine releasers and, later, he found that this property is shared by opium alkaloids and by a phenylethylamine derivative, compound 48/80, the most active known releaser. One of the outstanding recent contributions to pharmacology and therapeutics is his discovery, with Zaimis, of the actions of the methonium compounds - decamethonium a potent neuromuscular, and hexamethonium a potent ganglion blocking substance. His analysis of their mode of action has since become the model for such studies and led to the distinction between block by depolarisation and competition. Hexamethonium became the first effective drug in the treatment of malignant hypertension and of great value in cranial and plastic surgery. During the war he worked for the Royal Naval Personnel Research Committee on submarine physiology. "
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