XRCC1

XRCC1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3LQC, 1CDZ, 1XNA, 1XNT, 2D8M, 2W3O, 3K75, 3K77, 5E6Q
Identifiers
Aliases	XRCC1, RCC, X-ray repair complementing defective repair in Chinese hamster cells 1, X-ray repair cross complementing 1
External IDs	OMIM: 194360 MGI: 99137 HomoloGene: 31368 GeneCards: XRCC1
Gene ontology Molecular function • damaged DNA binding • enzyme binding • protein binding • DNA ligase activity • 3' overhang single-stranded DNA endodeoxyribonuclease activity • oxidized DNA binding Cellular component • nucleoplasm • nuclear chromosome, telomeric region • ERCC4-ERCC1 complex • nucleus • nucleolus • nuclear chromatin Biological process • single strand break repair • nucleotide-excision repair, DNA gap filling • transcription-coupled nucleotide-excision repair • response to hypoxia • response to organic substance • double-strand break repair via homologous recombination • response to drug • cellular response to DNA damage stimulus • base-excision repair, DNA ligation • hippocampus development • DNA repair • double-strand break repair via nonhomologous end joining • negative regulation of protection from non-homologous end joining at telomere • telomeric DNA-containing double minutes formation • base-excision repair • negative regulation of protein ADP-ribosylation • positive regulation of single strand break repair • positive regulation of DNA ligase activity Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	7515	22594
Ensembl	n/a	ENSMUSG00000051768
UniProt	P18887	Q60596
RefSeq (mRNA)	NM_006297	NM_009532
RefSeq (protein)	NP_006288	NP_033558
Location (UCSC)	n/a	Chr 7: 24.55 – 24.57 Mb
PubMed search

XRCC1_N
nmr solution structure of the single-strand break repair protein xrcc1-n-terminal domain
Identifiers
Symbol	XRCC1_N
Pfam	PF01834
Pfam clan	CL0202
InterPro	IPR002706
SCOP	1xnt
SUPERFAMILY	1xnt
Available protein structures: Pfam structures PDB RCSB PDB; PDBe; PDBj PDBsum structure summary

3LQC, 1CDZ, 1XNA, 1XNT, 2D8M, 2W3O, 3K75, 3K77, 5E6Q

7515

22594

n/a

ENSMUSG00000051768

P18887

Q60596

NM_006297

NM_009532

NP_006288

NP_033558

DNA repair protein XRCC1 also known as X-ray repair cross-complementing protein 1 is a protein that in humans is encoded by the XRCC1 gene. XRCC1 is involved in DNA repair where it complexes with DNA ligase III.