ZEB2

ZEB2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2DA7
Identifiers
Aliases	ZEB2, HSPC082, SIP-1, SIP1, SMADIP1, ZFHX1B, zinc finger E-box binding homeobox 2
External IDs	OMIM: 605802 MGI: 1344407 HomoloGene: 8868 GeneCards: ZEB2
Genetically Related Diseases
schizophrenia, renal cell carcinoma
Gene ontology Molecular function • DNA binding • phosphatase regulator activity • metal ion binding • protein binding • nucleic acid binding • transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding • transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding • R-SMAD binding Cellular component • nucleus • nucleolus • cytosol Biological process • regulation of transcription, DNA-templated • nervous system development • transcription, DNA-templated • positive regulation of melanin biosynthetic process • negative regulation of transcription from RNA polymerase II promoter • neural crest cell migration • somitogenesis • neural tube closure • transcription from RNA polymerase II promoter • central nervous system development • corpus callosum morphogenesis • hippocampus development • cell proliferation in forebrain • corticospinal tract morphogenesis • positive regulation of Wnt signaling pathway • positive regulation of JUN kinase activity • positive regulation of melanocyte differentiation • positive regulation of transcription from RNA polymerase II promoter • developmental pigmentation • embryonic morphogenesis • collateral sprouting • positive regulation of axonogenesis • mammillary axonal complex development • melanocyte migration • positive regulation of lens fiber cell differentiation • regulation of melanosome organization Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	9839	24136
Ensembl	ENSG00000169554	ENSMUSG00000026872
UniProt	O60315	Q9R0G7
RefSeq (mRNA)	NM_001171653 NM_014795	NM_015753 NM_001289521
RefSeq (protein)	NP_001165124 NP_055610	NP_001276450.1 NP_056568.2 NP_001276450 NP_056568
Location (UCSC)	Chr 2: 144.38 – 144.52 Mb	Chr 2: 44.98 – 45.12 Mb
PubMed search

2DA7

9839

24136

ENSG00000169554

ENSMUSG00000026872

O60315

Q9R0G7

NM_001171653
NM_014795

NM_015753
NM_001289521

NP_001165124
NP_055610

NP_001276450.1
NP_056568.2
NP_001276450
NP_056568

Zinc finger E-box-binding homeobox 2 is a protein that in humans is encoded by the ZEB2 gene. The ZEB2 protein is a transcription factor that plays a role in the transforming growth factor β (TGFβ) signaling pathways that are essential during early fetal development.

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Wikipedia