Zolazepam

Zolazepam
Clinical data


Trade names	Telazol (in combination with tiletamine)
AHFS/Drugs.com	International Drug Names
ATC code	none
Identifiers
IUPAC name 4-(2-fluorophenyl)-1,3,8-trimethyl-6H-pyrazolo[3,4-e][1,4]diazepin-7-one
CAS Number	31352-82-6^Y
PubChem CID	35775
ChemSpider	32907^Y
UNII	G1R474U58U
ECHA InfoCard	100.118.306
Chemical and physical data
Formula	C₁₅H₁₅FN₄O
Molar mass	286.304 g/mol
3D model (Jmol)	Interactive image
SMILES FC1=CC=CC=C1C2=NCC(N(C)C3=C2C(C)=NN3C)=O
InChI InChI=1S/C15H15FN4O/c1-9-13-14(10-6-4-5-7-11(10)16)17-8-12(21)19(2)15(13)20(3)18-9/h4-7H,8H2,1-3H3^Y Key:GDSCFOSHSOWNDL-UHFFFAOYSA-N^Y

Zolazepam (Flupyrazapon) is a pyrazolodiazepinone derivative structurally related to the benzodiazepine drugs, which is used as an anaesthetic for a wide range of animals in veterinary medicine. Zolazepam is usually administered in combination with other drugs such as the NMDA antagonist tiletamine or the α2 adrenergic receptor agonist xylazine, depending on what purpose it is being used for. It is around four times the potency of diazepam (0.32 mg/kg versus 1.2 mg/kg in animal models) but it is both water-soluble and un-ionized at physiological pH meaning that its onset is very fast.

Zolazepam was developed by Horace A. de Wald and Donald E. Butler for Parke-Davis and was the result of a very detailed analysis of the benzodiazepine structure (U.S. Patent 3,558,605 filed in 1969).

Zolazepam, in combination with tiletamine, has been used in the tranquilization of wild animals, such as gorillas and polar bears, and has been found to be superior to ketamine because of reduced side-effects. A 1:1 mixture of zolazepam and tiletamine is sold under the name Telazol.

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Wikipedia