| Men's Singles | |
|---|---|
| 1981 U.S. Clay Court Championships | |
| Champion |
|
| Runner-up |
|
| Final score | 4–6, 6–4, 6–2 |
Second-seed José Luis Clerc retained the title by defeating Ivan Lendl in the final and claimed first prize money of $32,000.
A champion seed is indicated in bold text while text in italics indicates the round in which that seed was eliminated.