1981 U.S. Clay Court Championships – Women's Singles
| Women's Singles | |
|---|---|
| 1981 U.S. Clay Court Championships | |
| Champion |
 Andrea Jaeger
|
| Runner-up |
 Virginia Ruzici
|
| Final score | 6–1, 6–0 |
Top-seed Andrea Jaeger won the final and $27,500 first prize money by defeating second-seeded Virginia Ruzici in the final.
The top eight seeds received a bye into the second round. A champion seed is indicated in bold text while text in italics indicates the round in which that seed was eliminated.
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