| Doubles | |
|---|---|
| 2010 Fifth Third Bank Tennis Championships | |
| Champions |
|
| Runners-up |
|
| Final score | 5–7, 6–4, [10–6] |
Kevin Anderson and Ryler DeHeart are the defending champions, but both chose not to participate.
Raven Klaasen and Izak van der Merwe won in the final against Kaden Hensel and Adam Hubble 5–7, 6–4, [10–6].