| Singles | |
|---|---|
| 2010 Fifth Third Bank Tennis Championships | |
| Champion |
|
| Runner-up |
|
| Final score | 6–4, 7–6(2) |
Harel Levy was the winner in 2009, but he chose to not participate this year.
Carsten Ball became the new champion, after won 6–4, 7–6(2), against Jesse Levine.