The 2010 season was Santos Futebol Clube's ninety-eighth season in existence and the club's fifty-one consecutive season in the top flight of Brazilian football.

On 4 December 2009, Luis Álvaro de Oliveira Ribeiro was elect President for the next two years.

This season marked the new Meninos da Vila generation, where Neymar, Ganso, Rafael, Wesley, André, alongside Robinho (who joined the club on a six-month loan deal) and others players, helped Santos won their 18th Campeonato Paulista title, beating Santo André in the finals. Santos also won the Copa do Brasil title, winning for the first time in history. It was the culmination of a campaign marked by a devastating team with relentless wins, as against Naviraiense 10–0 and 8–1 against Guarani, game in which Neymar scored five goals. In the second half of the year, losses of key players as Wesley (sold to Werder Bremen),André (sold to Dynamo Kyiv),Robinho (who returned to Manchester City),Ganso (who suffered an Anterior cruciate ligament injury), and the dismissal of coach Dorival Junior after a misunderstanding involving Neymar, Santos was unable to go beyond an 8th place in the Campeonato Brasileiro and postponed the conquest of the "triple crown" (symbolic title given to whoever wins in the same year, the State Championship, the Brazil Cup and Brazil League).

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