2012 Mutua Madrid Open – Men's Singles
| Men's Singles | |
|---|---|
| 2012 Mutua Madrid Open | |
| Champion |
 Roger Federer
|
| Runner-up |
 Tomáš Berdych
|
| Final score | 3–6, 7–5, 7–5 |
Novak Djokovic was the defending champion, but lost to Janko Tipsarević in the quarterfinals.
Roger Federer won his record-tying twentieth Masters 1000 title and third title at Madrid by defeating Tomáš Berdych 3–6, 7–5, 7–5 in the final. With this win, Federer overtook Rafael Nadal for the No. 2 ranking.
The top eight seeds receive a bye into the second round.
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