| Women's Singles | |
|---|---|
| 2012 Mutua Madrid Open | |
| Champion |
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| Runner-up |
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| Final score | 6–1, 6–3 |
Petra Kvitová was the defending champion, but lost to qualifier Lucie Hradecká in the second round.
Serena Williams won the tournament, defeating World No. 1 Victoria Azarenka in straight sets, 6–1, 6–3. Azarenka lost in the final for the second year in a row.
Click on the seed number of a player to go to their draw section.