| Names | |
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IUPAC name
3-(4-hydroxyphenyl)-2-oxo-propanoic acid
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| Other names
4-Hydroxyphenylpyruvate
p-Hydroxyphenylpyruvic acid p-Hydroxyphenylpyruvate |
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| Identifiers | |
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3D model (JSmol)
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| ChEBI | |
| ChEMBL | |
| ChemSpider | |
| DrugBank | |
| ECHA InfoCard | 100.005.322 |
| KEGG | |
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PubChem CID
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| Properties | |
| C9H8O4 | |
| Molar mass | 180.157 g/mol |
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Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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| Infobox references | |
4-Hydroxyphenylpyruvic acid (4-HPPA) is an intermediate in the metabolism of the amino acid phenylalanine. The aromatic side chain of phenylalanine is hydroxylated by the enzyme phenylalanine hydroxylase to form tyrosine. The conversion from tyrosine to 4-HPPA is in turn catalyzed by tyrosine aminotransferase. Additionally, 4-HPPA can be converted to homogentisic acid which is one of the precursors to ochronotic pigment.
It is an intermediary compound in the biosynthesis of scytonemin.