A1CF

A1CF
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2CPD
Identifiers
Aliases	A1CF, ACF, ACF64, ACF65, APOBEC1CF, ASP, APOBEC1 complementation factor
External IDs	MGI: 1917115 HomoloGene: 16363 GeneCards: A1CF
Gene location (Human) Chr. Chromosome 10 (human) Band 10q11.23 Start 50,799,409 bp End 50,885,675 bp
Gene location (Mouse) Chr. Chromosome 19 (mouse) Band 19|19 C1 Start 31,868,761 bp End 31,949,406 bp
RNA expression pattern More reference expression data
Gene ontology Molecular function • nucleic acid binding • double-stranded RNA binding • protein binding • single-stranded RNA binding • RNA binding Cellular component • cytoplasm • apolipoprotein B mRNA editing enzyme complex • endoplasmic reticulum • nucleus • nucleoplasm Biological process • mRNA processing • protein stabilization • cytidine to uridine editing • mRNA modification Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	29974	69865
Ensembl	ENSG00000148584	ENSMUSG00000052595
UniProt	Q9NQ94	Q5YD48
RefSeq (mRNA)	NM_001198818 NM_001198819 NM_001198820 NM_014576 NM_138932 NM_138933	NM_001081074
RefSeq (protein)	NP_001185747 NP_001185748 NP_001185749 NP_055391 NP_620310 NP_620311	NP_001074543
Location (UCSC)	Chr 10: 50.8 – 50.89 Mb	Chr 10: 31.87 – 31.95 Mb
PubMed search

2CPD

29974

69865

ENSG00000148584

ENSMUSG00000052595

Q9NQ94

Q5YD48

NM_138933

NM_001081074

NP_620311

NP_001074543

APOBEC1 complementation factor is a protein that in humans is encoded by the A1CF gene.

Alternative splicing occurs at this locus and three full-length transcript variants, encoding three distinct isoforms, have been described. Additional splicing has been observed but the full-length nature of these variants has not been determined.

Mammalian apolipoprotein B mRNA undergoes site-specific C to U deamination, which is mediated by a multi-component enzyme complex containing a minimal core composed of APOBEC1 and a complementation factor encoded by this gene. The gene product has three non-identical RNA recognition motifs and belongs to the hnRNP R family of RNA-binding proteins. It has been proposed that this complementation factor functions as an RNA-binding subunit and docks APOBEC1 to deaminate the upstream cytidine. Studies suggest that the protein may also be involved in other RNA editing or RNA processing events.

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Wikipedia