APOBEC1

APOBEC1
Identifiers
Aliases	APOBEC1, APOBEC-1, BEDP, CDAR1, HEPR, apolipoprotein B mRNA editing enzyme catalytic subunit 1
External IDs	MGI: 103298 HomoloGene: 1243 GeneCards: APOBEC1
Gene ontology Molecular function • enzyme activator activity • AU-rich element binding • hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines • protein binding • mRNA binding • ribonucleoprotein complex binding • cytidine deaminase activity • protein domain specific binding • RNA binding • catalytic activity • zinc ion binding • hydrolase activity • cytosine deaminase activity • metal ion binding Cellular component • nucleus • nucleoplasm • cytoplasm Biological process • DNA cytosine deamination • cellular response to insulin stimulus • response to osmotic stress • mRNA processing • RNA processing • response to calcium ion • response to ethanol • regulation of cell proliferation • response to zinc ion • defense response to virus • cytidine to uridine editing • response to gamma radiation • mRNA stabilization • DNA demethylation • lipoprotein metabolic process • lipoprotein transport • positive regulation of catalytic activity • lipoprotein biosynthetic process • lipid metabolic process • negative regulation of methylation-dependent chromatin silencing • positive regulation of mRNA modification • response to drug • cytidine deamination • mRNA modification • triglyceride metabolic process • negative regulation of triglyceride metabolic process Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	339	11810
Ensembl	ENSG00000111701	ENSMUSG00000040613
UniProt	P41238	P51908
RefSeq (mRNA)	NM_005889 NM_001304566 NM_001644	NM_001134391 NM_031159
RefSeq (protein)	NP_001291495 NP_001635 NP_005880	NP_001127863 NP_112436
Location (UCSC)	Chr 12: 7.65 – 7.67 Mb	Chr 6: 122.58 – 122.6 Mb
PubMed search

339

11810

ENSG00000111701

ENSMUSG00000040613

P41238

P51908

NM_005889
NM_001304566
NM_001644

NM_001134391
NM_031159

NP_001291495
NP_001635
NP_005880

NP_001127863
NP_112436

Apolipoprotein B mRNA editing enzyme, catalytic polypeptide 1 also known as C->U-editing enzyme APOBEC-1 is a protein that in humans is encoded by the APOBEC1 gene.

This gene encodes a member of the APOBEC protein family and the cytidine deaminase enzyme family. The encoded protein forms a multiple-protein RNA editing holoenzyme with APOBEC1 complementation factor (A1CF). This holoenzyme is involved in the editing of cytosine-to-uracil (C-to-U) nucleotide bases in apolipoprotein B and neurofibromin 1 mRNAs.

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