C1QBP

C1QBP
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1P32, 3RPX
Identifiers
Aliases	C1QBP, GHABP1, SF2p32, gC1Q-R, gC1qR, p32, complement component 1, q subcomponent binding protein, complement C1q binding protein
External IDs	MGI: 1194505 HomoloGene: 31023 GeneCards: C1QBP
Gene ontology Molecular function • transcription corepressor activity • transcription factor binding • protein binding • hyaluronic acid binding • kininogen binding • mitochondrial ribosome binding • mRNA binding • protein kinase C binding • complement component C1q binding • adrenergic receptor binding Cellular component • cytosol • extracellular region • cell surface • mitochondrial matrix • nucleolus • cytoplasm • membrane • mitochondrion • nucleus • extracellular space • plasma membrane Biological process • blood coagulation, intrinsic pathway • positive regulation of mitochondrial translation • negative regulation of interferon-gamma production • positive regulation of protein kinase B signaling • negative regulation of MDA-5 signaling pathway • regulation of transcription, DNA-templated • adaptive immune response • ribosome biogenesis • negative regulation of defense response to virus • immune system process • mRNA processing • negative regulation of transcription from RNA polymerase II promoter • GO:0006350 transcription, DNA-templated • positive regulation of trophoblast cell migration • positive regulation of substrate adhesion-dependent cell spreading • mature ribosome assembly • negative regulation of mRNA splicing, via spliceosome • immune response • RNA splicing • positive regulation of neutrophil chemotaxis • complement activation, classical pathway • positive regulation of apoptotic process • phosphatidylinositol 3-kinase signaling • innate immune response • viral process • positive regulation of dendritic cell chemotaxis • regulation of complement activation • negative regulation of RIG-I signaling pathway • positive regulation of cell adhesion • negative regulation of interleukin-12 production • apoptotic process Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	708	12261
Ensembl	ENSG00000108561	ENSMUSG00000018446
UniProt	Q07021	O35658 Q8R5L1
RefSeq (mRNA)	NM_001212	NM_007573
RefSeq (protein)	NP_001203	NP_031599
Location (UCSC)	Chr 17: 5.43 – 5.45 Mb	Chr 11: 70.98 – 70.98 Mb
PubMed search

1P32, 3RPX

708

12261

ENSG00000108561

ENSMUSG00000018446

Q07021

O35658
Q8R5L1

NM_001212

NM_007573

NP_001203

NP_031599

Complement component 1 Q subcomponent-binding protein, mitochondrial is a protein that in humans is encoded by the C1QBP gene.

The human complement subcomponent C1q associates with C1r and C1s in order to yield the first component of the serum complement system. The protein encoded by this gene is known to bind to the globular heads of C1q molecules and inhibit C1 activation. This protein has also been identified as the p32 subunit of pre-mRNA splicing factor SF2, as well as a hyaluronic acid-binding protein.

C1QBP has been shown to interact with Protein kinase D1,BAT2,PRKCD,PKC alpha and Protein kinase Mζ.

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Wikipedia