CD30

TNFRSF8
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1D01
Identifiers
Aliases	TNFRSF8, CD30, D1S166E, Ki-1, tumor necrosis factor receptor superfamily member 8
External IDs	OMIM: 153243 MGI: 99908 HomoloGene: 949 GeneCards: TNFRSF8
Gene ontology Molecular function • transmembrane signaling receptor activity • tumor necrosis factor-activated receptor activity • nerve growth factor binding Cellular component • cytoplasm • integral component of membrane • integral component of plasma membrane • extracellular exosome • membrane • plasma membrane • nucleus • neuron projection Biological process • apoptotic signaling pathway • cellular response to mechanical stimulus • response to lipopolysaccharide • inflammatory response • immune response • positive regulation of tumor necrosis factor biosynthetic process • signal transduction • negative regulation of cell proliferation • positive regulation of TRAIL biosynthetic process • positive regulation of apoptotic process • tumor necrosis factor-mediated signaling pathway • axon guidance • negative regulation of neuron projection development Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	943	21941
Ensembl	ENSG00000120949	ENSMUSG00000028602
UniProt	P28908	Q60846
RefSeq (mRNA)	NM_001243 NM_001281430 NM_152942	NM_009401
RefSeq (protein)	NP_001234 NP_001268359	NP_033427.1 NP_033427
Location (UCSC)	Chr 1: 12.06 – 12.14 Mb	Chr 4: 145.27 – 145.32 Mb
PubMed search

1D01

943

21941

ENSG00000120949

ENSMUSG00000028602

P28908

Q60846

NM_001243
NM_001281430
NM_152942

NM_009401

NP_001234
NP_001268359

NP_033427.1
NP_033427

CD30, also known as TNFRSF8, is a cell membrane protein of the tumor necrosis factor receptor family and tumor marker.

This receptor is expressed by activated, but not by resting, T and B cells. TRAF2 and TRAF5 can interact with this receptor, and mediate the signal transduction that leads to the activation of NF-kappaB. It is a positive regulator of apoptosis, and also has been shown to limit the proliferative potential of autoreactive CD8 effector T cells and protect the body against autoimmunity. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported.

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Wikipedia