CNTN2

CNTN2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2OM5
Identifiers
Aliases	CNTN2, AXT, FAME5, TAG-1, TAX, TAX1, contactin 2
External IDs	MGI: 104518 HomoloGene: 3720 GeneCards: CNTN2
Gene ontology Molecular function • glycoprotein binding • protein self-association • identical protein binding • carbohydrate binding Cellular component • membrane • myelin sheath • voltage-gated potassium channel complex • plasma membrane • node of Ranvier • synapse • integral component of plasma membrane • cell surface • axon • neuronal cell body • anchored component of membrane • neuron projection • juxtaparanode region of axon Biological process • clustering of voltage-gated potassium channels • negative regulation of neuron differentiation • central nervous system myelination • receptor internalization • neuron migration • learning • presynaptic membrane organization • regulation of astrocyte differentiation • regulation of axon diameter • cell adhesion • positive regulation of protein processing • establishment of protein localization to juxtaparanode region of axon • positive regulation of adenosine receptor signaling pathway • cerebral cortex GABAergic interneuron migration • regulation of neuronal synaptic plasticity • protein localization to juxtaparanode region of axon • regulation of cell morphogenesis involved in differentiation • neuron projection development • axonal fasciculation • microtubule cytoskeleton organization • adult walking behavior • axon guidance • nervous system development Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	6900	21367
Ensembl	ENSG00000184144	ENSMUSG00000053024
UniProt	Q02246	Q61330
RefSeq (mRNA)	NM_005076 NM_001346083	NM_011531 NM_177129
RefSeq (protein)	NP_001333012 NP_005067	NP_796103.2 NP_796103
Location (UCSC)	Chr 1: 205.04 – 205.08 Mb	Chr 1: 132.51 – 132.54 Mb
PubMed search

2OM5

6900

21367

ENSG00000184144

ENSMUSG00000053024

Q02246

Q61330

NM_005076
NM_001346083

NM_011531
NM_177129

NP_001333012
NP_005067

NP_796103.2
NP_796103

Contactin-2 is a protein that in humans is encoded by the CNTN2 gene.

The protein encoded by this gene is a member of the immunoglobulin superfamily. It is a glycosylphosphatidylinositol (GPI)-anchored neuronal membrane protein that functions as a cell adhesion molecule. It may play a role in the formation of axon connections in the developing nervous system. It may also be involved in glial tumorigenesis and may provide a potential target for therapeutic intervention.

CNTN2 has been shown to interact with CNTNAP2 and NFYB.

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Wikipedia