DEK (gene)

DEK
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1Q1V, 2JX3
Identifiers
Aliases	DEK, D6S231E, DEK proto-oncogene
External IDs	MGI: 1926209 HomoloGene: 2593 GeneCards: DEK
Gene ontology Molecular function • DNA binding • histone binding • chromatin binding • RNA binding Cellular component • nucleoplasm • contractile fiber • nucleus Biological process • positive regulation of gene expression, epigenetic • viral genome replication • regulation of double-strand break repair via nonhomologous end joining • transcription from RNA polymerase II promoter • regulation of transcription from RNA polymerase II promoter • regulation of double-strand break repair • signal transduction • covalent chromatin modification • chromatin remodeling Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	7913	110052
Ensembl	ENSG00000124795	ENSMUSG00000021377
UniProt	P35659	Q7TNV0
RefSeq (mRNA)	NM_001134709 NM_003472	NM_025900
RefSeq (protein)	NP_001128181 NP_003463	NP_080176.2 NP_080176
Location (UCSC)	Chr 6: 18.22 – 18.26 Mb	Chr 13: 47.08 – 47.11 Mb
PubMed search

1Q1V, 2JX3

7913

110052

ENSG00000124795

ENSMUSG00000021377

P35659

Q7TNV0

NM_001134709
NM_003472

NM_025900

NP_001128181
NP_003463

NP_080176.2
NP_080176

The human DEK gene encodes the DEK protein.

This gene encodes a protein with one SAP domain. The protein binds to cruciform and superhelical DNA and induces positive supercoils into closed circular DNA. It is also involved in splice site selection during mRNA processing. Chromosomal aberrations involving this region increased expression of this gene and the presence of antibodies against this protein are all associated with various diseases.

DEK interacts with TFAP2A.

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Wikipedia