EIF1

Available structures

Human UniProt search: PDBe RCSB

List of PDB id codes
2IF1, 4KZX, 4KZY

Identifiers

Aliases

EIF1, A121, EIF-1, EIF1A, ISO1, SUI1, eukaryotic translation initiation factor 1, Eukaryotic initiation factor 1

External IDs

HomoloGene: 130538 GeneCards: EIF1

Gene ontology
Molecular function	• translation factor activity, RNA binding • translation initiation factor activity • RNA binding
Cellular component	• cytoplasm • nucleus
Biological process	• translational initiation • response to stress • dosage compensation by inactivation of X chromosome • translation • regulation of translational initiation
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


10209


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Ensembl


ENSG00000173812


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UniProt


P41567


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RefSeq (mRNA)


NM_005801


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RefSeq (protein)


NP_005792


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Location (UCSC)

Chr 17: 41.69 – 41.69 Mb

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PubMed search

n/a

2IF1, 4KZX, 4KZY

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Eukaryotic translation initiation factor 1 (eIF1) is a protein that in humans is encoded by the EIF1 gene.

eIF1 interacts with the eukaryotic small (40S) ribosomal subunit and eIF3, and is a component of the 43S preinitiation complex (PIC). eIF1 and eIF1A bind cooperatively to the 40S to stabilize an "open" conformation of the preinitiation complex (PIC) during eukaryotic translation initiation. eIF1 binds to a region near the ribosomal A-site in the 40S subunit and functions in a manner similar to the structurally related bacterial counterpart IF1.

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Wikipedia