Fibroblast growth factor 1

FGF1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4QO3, 1AXM, 1DJS, 1DZC, 1DZD, 1E0O, 1EVT, 1HKN, 1JQZ, 1JT3, 1JT4, 1JT5, 1JT7, 1JTC, 1JY0, 1K5U, 1K5V, 1M16, 1NZK, 1P63, 1PZZ, 1Q03, 1Q04, 1RG8, 1RML, 1RY7, 1YTO, 1Z2V, 1Z4S, 2AFG, 2AQZ, 2AXM, 2ERM, 2HW9, 2HWA, 2HWM, 2HZ9, 2K43, 2K4A, 2K8R, 2KI4, 2KI6, 2NTD, 2Q9X, 2RQ9, 3B9U, 3BA4, 3BA5, 3BA7, 3BAD, 3BAG, 3BAH, 3BAO, 3BAQ, 3BAU, 3BAV, 3BB2, 3CQA, 3CRG, 3CRH, 3CRI, 3CU1, 3FGM, 3FJ8, 3FJ9, 3FJA, 3FJB, 3FJC, 3FJD, 3FJE, 3FJF, 3FJH, 3FJI, 3FJJ, 3FJK, 3HOM, 3JUT, 3K1X, 3O3Q, 3OJ2, 3OJM, 3OJV, 3UD7, 3UD8, 3UD9, 3UDA, 4J23, 4Q91, 4Q9G, 4Q9P, 4QAL, 4QBC, 4QBV, 4QC4, 4XKI, 4YOL
Identifiers
Aliases	FGF1, AFGF, ECGF, ECGF-beta, ECGFA, ECGFB, FGF-1, FGF-alpha, FGFA, GLIO703, HBGF-1, HBGF1, fibroblast growth factor 1
External IDs	OMIM: 131220 MGI: 95515 HomoloGene: 625 GeneCards: FGF1
Gene location (Human) Chr. Chromosome 5 (human) Band No data available Start 142,592,178 bp End 142,698,070 bp
Gene location (Mouse) Chr. Chromosome 18 (mouse) Band No data available Start 38,838,673 bp End 38,929,404 bp
RNA expression pattern More reference expression data
Gene ontology Molecular function • S100 protein binding • Hsp70 protein binding • protein binding • growth factor activity • protein tyrosine kinase activity • Ras guanyl-nucleotide exchange factor activity • phosphatidylinositol-4,5-bisphosphate 3-kinase activity • fibroblast growth factor receptor binding • integrin binding • 1-phosphatidylinositol-3-kinase activity • heparin binding Cellular component • cytoplasm • cytosol • proteinaceous extracellular matrix • nucleoplasm • extracellular region • cell cortex • nucleolus • nucleus • extracellular space Biological process • cell differentiation • cellular response to heat • positive regulation of protein phosphorylation • positive regulation of MAP kinase activity • organ induction • lung development • positive regulation of epithelial cell proliferation • anatomical structure morphogenesis • positive regulation of intracellular signal transduction • branch elongation involved in ureteric bud branching • positive regulation of angiogenesis • MAPK cascade • multicellular organism development • mesonephric epithelium development • angiogenesis • positive regulation of ERK1 and ERK2 cascade • regulation of endothelial cell chemotaxis to fibroblast growth factor • positive regulation of cholesterol biosynthetic process • cell proliferation • positive regulation of cell division • phosphatidylinositol-mediated signaling • positive regulation of transcription from RNA polymerase II promoter • signal transduction • positive regulation of GTPase activity • phosphatidylinositol phosphorylation • peptidyl-tyrosine phosphorylation • positive regulation of sprouting angiogenesis • activation of MAPK activity • fibroblast growth factor receptor signaling pathway • positive regulation of cell proliferation • regulation of phosphatidylinositol 3-kinase signaling • phosphatidylinositol-3-phosphate biosynthetic process • regulation of endothelial tube morphogenesis • positive regulation of cell migration • positive regulation of endothelial cell migration • activation of protein kinase B activity • interleukin-7-mediated signaling pathway Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	2246	14164
Ensembl	ENSG00000113578	ENSMUSG00000036585
UniProt	P05230	P61148
RefSeq (mRNA)	NM_000800 NM_001144892 NM_001144934 NM_001144935 NM_001257205 NM_001257206 NM_001257207 NM_001257208 NM_001257209 NM_001257210 NM_001257211 NM_001257212 NM_033136 NM_033137	NM_010197
RefSeq (protein)	NP_000791 NP_001138364 NP_001138406 NP_001138407 NP_001244134 NP_001244135 NP_001244136 NP_001244137 NP_001244138 NP_001244139 NP_001244140 NP_001244141 NP_149127 NP_149128	NP_034327
Location (UCSC)	Chr 5: 142.59 – 142.7 Mb	Chr 5: 38.84 – 38.93 Mb
PubMed search

4QO3, 1AXM, 1DJS, 1DZC, 1DZD, 1E0O, 1EVT, 1HKN, 1JQZ, 1JT3, 1JT4, 1JT5, 1JT7, 1JTC, 1JY0, 1K5U, 1K5V, 1M16, 1NZK, 1P63, 1PZZ, 1Q03, 1Q04, 1RG8, 1RML, 1RY7, 1YTO, 1Z2V, 1Z4S, 2AFG, 2AQZ, 2AXM, 2ERM, 2HW9, 2HWA, 2HWM, 2HZ9, 2K43, 2K4A, 2K8R, 2KI4, 2KI6, 2NTD, 2Q9X, 2RQ9, 3B9U, 3BA4, 3BA5, 3BA7, 3BAD, 3BAG, 3BAH, 3BAO, 3BAQ, 3BAU, 3BAV, 3BB2, 3CQA, 3CRG, 3CRH, 3CRI, 3CU1, 3FGM, 3FJ8, 3FJ9, 3FJA, 3FJB, 3FJC, 3FJD, 3FJE, 3FJF, 3FJH, 3FJI, 3FJJ, 3FJK, 3HOM, 3JUT, 3K1X, 3O3Q, 3OJ2, 3OJM, 3OJV, 3UD7, 3UD8, 3UD9, 3UDA, 4J23, 4Q91, 4Q9G, 4Q9P, 4QAL, 4QBC, 4QBV, 4QC4, 4XKI, 4YOL

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