Hepcidin

HAMP
Available structures PDB Human UniProt search: PDBe RCSB List of PDB id codes 1M4E, 1M4F, 2KEF, 3H0T, 4QAE
Identifiers
Aliases	HAMP, HEPC, HFE2B, LEAP1, PLTR, hepcidin antimicrobial peptide
External IDs	OMIM: 606464 HomoloGene: 81623 GeneCards: HAMP
Gene ontology Molecular function • hormone activity • iron channel inhibitor activity • receptor binding Cellular component • cytoplasm • extracellular region • apical cortex • intercalated disc • cell • extracellular space Biological process • negative regulation of ferrous iron export • negative regulation of intestinal absorption • positive regulation of receptor internalization • negative regulation of transcription from RNA polymerase II promoter • killing of cells of other organism • defense response to fungus • negative regulation of iron channel activity • response to iron ion • multicellular organismal iron ion homeostasis • defense response to bacterium • immune response • positive regulation of receptor catabolic process • positive regulation of protein polyubiquitination • negative regulation of ion transmembrane transporter activity • cellular iron ion homeostasis • cellular response to lipopolysaccharide • aging • cellular response to tumor necrosis factor • liver regeneration • cellular response to bile acid • cellular response to interleukin-6 • response to iron ion starvation • response to vitamin A • response to erythropoietin • positive regulation of cell growth involved in cardiac muscle cell development • response to ethanol • acute-phase response • cellular response to X-ray • response to zinc ion • negative regulation of iron ion transmembrane transport Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	57817	n/a
Ensembl	ENSG00000105697	n/a
UniProt	P81172	n/a
RefSeq (mRNA)	NM_021175	n/a
RefSeq (protein)	NP_066998	n/a
Location (UCSC)	Chr 19: 35.28 – 35.29 Mb	n/a
PubMed search		n/a

Hepcidin
Solution structure of hepcidin-25.
Identifiers
Symbol	Hepcidin
Pfam	PF06446
InterPro	IPR010500
SCOP	1m4f
SUPERFAMILY	1m4f
OPM superfamily	162
OPM protein	1m4e
Available protein structures: Pfam structures PDB RCSB PDB; PDBe; PDBj PDBsum structure summary

Available protein structures:
Pfam	structures
PDB	RCSB PDB; PDBe; PDBj
PDBsum	structure summary

hepcidin antimicrobial peptide
Identifiers
Symbol	HAMP
Entrez	57817
HUGO	15598
OMIM	606464
RefSeq	NM_021175
UniProt	P81172
Other data
Locus	Chr. 19 q13.1

1M4E, 1M4F, 2KEF, 3H0T, 4QAE

57817

n/a

ENSG00000105697

n/a

P81172

n/a

NM_021175

n/a

NP_066998

n/a

Hepcidin is a protein that in humans is encoded by the HAMP gene. Hepcidin is a key regulator of the entry of iron into the circulation in mammals.

In states in which the hepcidin level is abnormally high such as inflammation, serum iron falls due to iron trapping within macrophages and liver cells and decreased gut iron absorption. This typically leads to anemia due to an inadequate amount of serum iron being available for developing red cells. When the hepcidin level is abnormally low such as in hemochromatosis, iron overload occurs due to increased ferroportin mediated iron efflux from storage and increased gut iron absorption.

In lab mice, hepcidin has been found to have anti-inflammatory properties. This is a negative feedback: it reduces the inflammation which caused the elevated hepcidin level.

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