IKZF4

IKZF4
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2MA7
Identifiers
Aliases	IKZF4, EOS, ZNFN1A4, IKAROS family zinc finger 4
External IDs	MGI: 1343139 HomoloGene: 69103 GeneCards: IKZF4
Genetically Related Diseases
vitiligo, type 1 diabetes mellitus, asthma, alopecia areata
Gene ontology Molecular function • transcription factor activity, sequence-specific DNA binding • nucleic acid binding • transcription regulatory region DNA binding • sequence-specific DNA binding • DNA binding • bHLH transcription factor binding • protein homodimerization activity • metal ion binding • protein heterodimerization activity Cellular component • nucleus • nucleoplasm • nuclear body Biological process • negative regulation of transcription, DNA-templated • regulation of transcription, DNA-templated • transcription, DNA-templated • positive regulation of transcription from RNA polymerase II promoter Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	64375	22781
Ensembl	ENSG00000123411	ENSMUSG00000002578
UniProt	Q9H2S9	Q8C208
RefSeq (mRNA)	NM_022465	NM_011772
RefSeq (protein)	NP_071910	NP_035902.2 NP_035902
Location (UCSC)	Chr 12: 56.01 – 56.04 Mb	Chr 10: 128.63 – 128.65 Mb
PubMed search

2MA7

64375

22781

ENSG00000123411

ENSMUSG00000002578

Q9H2S9

Q8C208

NM_022465

NM_011772

NP_071910

NP_035902.2
NP_035902

Zinc finger protein Eos is a protein that in humans is encoded by the IKZF4 gene.

Members of the Ikaros (ZNFN1A1; MIM 603023) family of transcription factors, which includes Eos, are expressed in lymphocytes and are implicated in the control of lymphoid development.[supplied by OMIM]

IKZF4 has been shown to interact with CTBP1 and IKZF1.

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Wikipedia