IL6ST

IL6ST
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1BJ8, 1BQU, 1I1R, 1P9M, 1PVH, 3L5H, 3L5I, 3L5J,%%s1BJ8, 1BQU, 1I1R, 1P9M, 1PVH, 3L5H, 3L5I, 3L5J, 1N2Q
Identifiers
Aliases	IL6ST, CD130, CDW130, GP130, IL-6RB, interleukin 6 signal transducer
External IDs	OMIM: 600694 MGI: 96560 HomoloGene: 1645 GeneCards: IL6ST
Gene location (Human) Chr. Chromosome 5 (human) Band 5q11.2 Start 55,935,095 bp End 55,994,993 bp
Gene location (Mouse) Chr. Chromosome 13 (mouse) Band 13 D2.2|13 63.73 cM Start 112,464,070 bp End 112,510,086 bp
Gene ontology Molecular function • interleukin-11 binding • leukemia inhibitory factor receptor activity • ciliary neurotrophic factor receptor binding • interleukin-27 receptor activity • ciliary neurotrophic factor receptor activity • cytokine receptor activity • protein homodimerization activity • interleukin-6 receptor binding • growth factor binding • interleukin-11 receptor activity • oncostatin-M receptor activity • interleukin-6 receptor activity • interleukin-6 binding • protein binding Cellular component • extracellular exosome • extracellular region • integral component of membrane • cell body • ciliary neurotrophic factor receptor complex • membrane • neuronal cell body • dendrite • plasma membrane • interleukin-6 receptor complex • oncostatin-M receptor complex • external side of plasma membrane • extracellular space Biological process • regulation of Notch signaling pathway • positive regulation of cardiac muscle hypertrophy • negative regulation of apoptotic process • negative regulation of interleukin-6-mediated signaling pathway • interleukin-11-mediated signaling pathway • response to cytokine • oncostatin-M-mediated signaling pathway • signal transduction • interleukin-27-mediated signaling pathway • positive regulation of adaptive immune response • ciliary neurotrophic factor-mediated signaling pathway • leukemia inhibitory factor signaling pathway • viral process • positive regulation of T cell proliferation • interleukin-6-mediated signaling pathway • positive regulation of acute inflammatory response • cytokine-mediated signaling pathway • positive regulation of astrocyte differentiation • positive regulation of osteoblast differentiation • glycogen metabolic process • positive regulation of vascular endothelial growth factor production • positive regulation of cell proliferation • positive regulation of tyrosine phosphorylation of STAT protein • interleukin-12-mediated signaling pathway Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	3572	16195
Ensembl	ENSG00000134352	ENSMUSG00000021756
UniProt	P40189 Q17RA0	Q00560
RefSeq (mRNA)	NM_001190981 NM_002184 NM_175767	NM_010560
RefSeq (protein)	NP_001177910 NP_002175 NP_786943 NP_002175.2 NP_001177910.1	NP_034690
Location (UCSC)	Chr 5: 55.94 – 55.99 Mb	Chr 13: 112.46 – 112.51 Mb
PubMed search

1BJ8, 1BQU, 1I1R, 1P9M, 1PVH, 3L5H, 3L5I, 3L5J,%%s1BJ8, 1BQU, 1I1R, 1P9M, 1PVH, 3L5H, 3L5I, 3L5J, 1N2Q

3572

16195

ENSG00000134352

ENSMUSG00000021756

P40189
Q17RA0

Q00560

...
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