Interleukin 15 receptor, alpha subunit

IL15RA
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2ERS, 2Z3Q, 2Z3R, 4GS7
Identifiers
Aliases	IL15RA, CD215, Interleukin 15 receptor, alpha subunit, interleukin 15 receptor subunit alpha
External IDs	MGI: 104644 HomoloGene: 1650 GeneCards: IL15RA
Gene ontology Molecular function • cytokine receptor activity • protein binding • signal transducer activity Cellular component • cytoplasmic vesicle • integral component of membrane • extracellular region • Golgi membrane • Golgi apparatus • nuclear membrane • endoplasmic reticulum membrane • cytoplasmic vesicle membrane • nucleus • endoplasmic reticulum • membrane • plasma membrane • extracellular space Biological process • cell proliferation • signal transduction • cytokine-mediated signaling pathway Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	3601	16169
Ensembl	ENSG00000134470	ENSMUSG00000023206
UniProt	Q13261	Q60819
RefSeq (mRNA)	NM_001243539 NM_001256765 NM_002189 NM_172200 NM_001351095 NM_001351096 NM_001351097	NM_001271497 NM_001271498 NM_001271499 NM_001271500 NM_001271501 NM_008358 NM_133836
RefSeq (protein)	NP_001230468 NP_001243694 NP_002180 NP_751950 NP_001338024 NP_001338025 NP_001338026	NP_001258426 NP_001258427 NP_001258428 NP_001258429 NP_001258430 NP_032384 NP_598597
Location (UCSC)	Chr 10: 5.94 – 5.98 Mb	Chr 2: 11.71 – 11.73 Mb
PubMed search

2ERS, 2Z3Q, 2Z3R, 4GS7

3601

16169

ENSG00000134470

ENSMUSG00000023206

Q13261

Q60819

NM_001351096
NM_001351097

NM_008358
NM_133836

NP_001338025
NP_001338026

NP_032384
NP_598597

Interleukin 15 receptor, alpha subunit is a subunit of the interleukin 15 receptor that in humans is encoded by the IL15RA gene.

The IL-15 receptor is composed of three subunits: IL-15R alpha, CD122, and CD132. Two of these subunits, CD122 and CD132, are shared with the receptor for IL-2, but IL-2 receptor has an additional subunit (CD25). The shared subunits contain the cytoplasmic motifs required for signal transduction, and this forms the basis of many overlapping biological activities of IL15 and IL2, although in vivo the two cytokines have separate biological effects. This may be due to effects of the respective alpha chains, which are unique to each receptor, the kinetics and affinity of cytokine-cytokine receptor binding, or due to the availability and concentration of each cytokine.

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Wikipedia