Interleukin 1 receptor, type II

IL1R2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3O4O
Identifiers
Aliases	IL1R2, CD121b, CDw121b, IL-1R-2, IL-1RT-2, IL-1RT2, IL1R2c, IL1RB, Interleukin 1 receptor, type II, interleukin 1 receptor type 2
External IDs	MGI: 96546 HomoloGene: 7783 GeneCards: IL1R2
Gene location (Human) Chr. Chromosome 2 (human) Band 2q11.2 Start 101,991,844 bp End 102,028,544 bp
Gene location (Mouse) Chr. Chromosome 1 (mouse) Band 1 B|1 18.65 cM Start 40,074,079 bp End 40,125,231 bp
RNA expression pattern More reference expression data
Gene ontology Molecular function • interleukin-1, Type II, blocking receptor activity • protein binding • interleukin-1 receptor activity • interleukin-1 binding Cellular component • integral component of membrane • extracellular region • plasma membrane • membrane • cytoplasm Biological process • immune response • cytokine-mediated signaling pathway • negative regulation of protein processing • negative regulation of cytokine production involved in inflammatory response • negative regulation of interleukin-1-mediated signaling pathway • negative regulation of interleukin-1 alpha secretion Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	7850	16178
Ensembl	ENSG00000115590	ENSMUSG00000026073
UniProt	P27930	P27931
RefSeq (mRNA)	NM_001261419 NM_004633 NM_173343	NM_010555
RefSeq (protein)	NP_001248348 NP_004624	NP_034685
Location (UCSC)	Chr 2: 101.99 – 102.03 Mb	Chr 2: 40.07 – 40.13 Mb
PubMed search

3O4O

7850

16178

ENSG00000115590

ENSMUSG00000026073

P27930

P27931

NM_001261419
NM_004633
NM_173343

NM_010555

NP_001248348
NP_004624

NP_034685

Interleukin 1 receptor, type II (IL-1R2) also known as CD121b (Cluster of Differentiation 121b) is an interleukin receptor. IL1R2 also denotes its human gene.

The protein encoded by this gene is a decoy receptor for certain cytokines that belongs to the interleukin-1 receptor family. This protein binds interleukin-1α (IL1A), interleukin-1β (IL1B), and interleukin 1 receptor antagonist (IL1Ra), preventing them from binding to their regular receptors and thereby inhibiting the transduction of their signaling. IL-1R2 protein also interacts non-productively with the second component of the signalling IL-1 receptor, namely IL-1RAcP, and a complex of the IL-1R2 and IL-1RAcP extracellular domains with interleukin-1 beta has been solved by X-ray crystallography.Interleukin 4 (IL4) is reported to antagonize the activity of interleukin 1 by inducing the expression and release of this cytokine. This gene and three other genes form a cytokine receptor gene cluster on chromosome 2q12. Two alternatively spliced transcript variants encoding the same protein have been reported.

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