KCNA3

KCNA3
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4BGC
Identifiers
Aliases	KCNA3, HGK5, HLK3, HPCN3, HUKIII, KV1.3, MK3, PCN3, potassium voltage-gated channel subfamily A member 3
External IDs	MGI: 96660 HomoloGene: 128570 GeneCards: KCNA3
Gene ontology Molecular function • outward rectifier potassium channel activity • potassium channel activity • voltage-gated ion channel activity • ion channel activity • voltage-gated potassium channel activity • delayed rectifier potassium channel activity Cellular component • membrane • voltage-gated potassium channel complex • plasma membrane • integral component of plasma membrane • axon • membrane raft • integral component of membrane Biological process • regulation of ion transmembrane transport • ion transport • potassium ion transport • transmembrane transport • transport • protein homooligomerization • potassium ion transmembrane transport Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	3738	16491
Ensembl	ENSG00000177272	ENSMUSG00000047959
UniProt	P22001	P16390
RefSeq (mRNA)	NM_002232	NM_008418
RefSeq (protein)	NP_002223	NP_032444.2 NP_032444
Location (UCSC)	Chr 1: 110.67 – 110.68 Mb	Chr 3: 107.04 – 107.04 Mb
PubMed search

4BGC

3738

16491

ENSG00000177272

ENSMUSG00000047959

P22001

P16390

NM_002232

NM_008418

NP_002223

NP_032444.2
NP_032444

Potassium voltage-gated channel, shaker-related subfamily, member 3, also known as KCNA3 or K_v1.3, is a protein that in humans is encoded by the KCNA3 gene.

Potassium channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes – shaker, shaw, shab, and shal – have been identified in Drosophila, and each has been shown to have human homolog(s).

This gene encodes a member of the potassium channel, voltage-gated, shaker-related subfamily. This member contains six membrane-spanning domains with a shaker-type repeat in the fourth segment. It belongs to the delayed rectifier class, members of which allow nerve cells to efficiently repolarize following an action potential. It plays an essential role in T cell proliferation and activation. This gene appears to be intronless and is clustered together with KCNA2 and KCNA10 genes on chromosome 1.

...
Wikipedia