Ku70

XRCC6
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1JEQ, 1JEY, 1JJR, 3RZX,%%s1JEQ, 1JEY
Identifiers
Aliases	XRCC6, X-ray repair complementing defective repair in Chinese hamster cells 6, CTC75, CTCBF, G22P1, KU70, ML8, TLAA, X-ray repair cross complementing 6
External IDs	MGI: 95606 HomoloGene: 37483 GeneCards: XRCC6
Gene ontology Molecular function • nucleotide binding • double-stranded telomeric DNA binding • telomeric DNA binding • helicase activity • 5'-deoxyribose-5-phosphate lyase activity • ATP-dependent DNA helicase activity • protein C-terminus binding • catalytic activity • protein binding • lyase activity • macromolecular complex binding • transcription regulatory region DNA binding • hydrolase activity • ATP binding • DNA binding • double-stranded DNA binding • damaged DNA binding • RNA binding Cellular component • cytosol • nuclear telomere cap complex • membrane • transcription factor complex • chromosome • nucleoplasm • nonhomologous end joining complex • nucleus • nuclear chromosome, telomeric region • Ku70:Ku80 complex • cytoplasm • extracellular region • secretory granule lumen • ficolin-1-rich granule lumen • protein-DNA complex • protein complex • nucleolus Biological process • double-strand break repair via classical nonhomologous end joining • protein heterotetramerization • regulation of transcription, DNA-templated • regulation of smooth muscle cell proliferation • transcription, DNA-templated • cellular response to DNA damage stimulus • positive regulation of transcription, DNA-templated • DNA ligation • establishment of integrated proviral latency • metabolic process • negative regulation of transcription, DNA-templated • double-strand break repair via nonhomologous end joining • telomere maintenance • positive regulation of type I interferon production • positive regulation of transcription from RNA polymerase II promoter • DNA duplex unwinding • DNA repair • cellular hyperosmotic salinity response • brain development • DNA recombination • neutrophil degranulation • cellular response to gamma radiation • cellular response to X-ray • positive regulation of protein kinase activity Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	2547	14375
Ensembl	ENSG00000196419	ENSMUSG00000022471
UniProt	P12956	P23475
RefSeq (mRNA)	NM_001469 NM_001288976 NM_001288977 NM_001288978	NM_010247
RefSeq (protein)	NP_001275905 NP_001275906 NP_001275907 NP_001460 NP_001275905.1 NP_001460.1	NP_034377
Location (UCSC)	Chr 22: 41.62 – 41.66 Mb	Chr 15: 81.99 – 82.04 Mb
PubMed search

1JEQ, 1JEY, 1JJR, 3RZX,%%s1JEQ, 1JEY

2547

14375

ENSG00000196419

ENSMUSG00000022471

P12956

P23475

NM_001469
NM_001288976
NM_001288977
NM_001288978

NM_010247

NP_001460.1

NP_034377

Ku70 is a protein that, in humans, is encoded by the XRCC6 gene.

Together, Ku70 and Ku80 make up the Ku heterodimer, which binds to DNA double-strand break ends and is required for the non-homologous end joining (NHEJ) pathway of DNA repair. It is also required for V(D)J recombination, which utilizes the NHEJ pathway to promote antigen diversity in the mammalian immune system.

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