Ku80

XRCC5
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1JEQ, 1JEY, 1Q2Z, 1RW2, 3RZ9
Identifiers
Aliases	XRCC5, KARP-1, KARP1, KU80, KUB2, Ku86, NFIV, Ku80, X-ray repair complementing defective repair in Chinese hamster cells 5, X-ray repair cross complementing 5
External IDs	MGI: 104517 HomoloGene: 40681 GeneCards: XRCC5
Gene ontology Molecular function • DNA binding • nucleotide binding • double-stranded telomeric DNA binding • telomeric DNA binding • helicase activity • 5'-deoxyribose-5-phosphate lyase activity • ATP-dependent DNA helicase activity • hydrolase activity, acting on acid anhydrides • protein C-terminus binding • protein binding • macromolecular complex binding • transcription regulatory region DNA binding • hydrolase activity • ATP binding • ubiquitin protein ligase binding • double-stranded DNA binding • damaged DNA binding • RNA binding Cellular component • cytoplasm • cytosol • nuclear telomere cap complex • membrane • plasma membrane • nucleoplasm • chromosome • nucleolus • Ku70:Ku80 complex • nonhomologous end joining complex • nuclear chromosome, telomeric region • nucleus • protein complex • extracellular region • secretory granule lumen Biological process • DNA recombination • regulation of transcription, DNA-templated • regulation of smooth muscle cell proliferation • transcription, DNA-templated • cellular response to DNA damage stimulus • positive regulation of neurogenesis • hematopoietic stem cell differentiation • double-strand break repair • negative regulation of t-circle formation • establishment of integrated proviral latency • cell proliferation • telomere maintenance • negative regulation of transcription, DNA-templated • positive regulation of type I interferon production • response to drug • cellular hyperosmotic salinity response • DNA repair • DNA duplex unwinding • brain development • cellular response to fatty acid • double-strand break repair via nonhomologous end joining • neutrophil degranulation • cellular response to gamma radiation • cellular response to X-ray Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	7520	22596
Ensembl	ENSG00000079246	ENSMUSG00000026187
UniProt	P13010	P27641
RefSeq (mRNA)	NM_021141	NM_009533
RefSeq (protein)	NP_066964	NP_033559.2 NP_033559
Location (UCSC)	Chr 2: 216.11 – 216.21 Mb	Chr 1: 72.31 – 72.39 Mb
PubMed search

1JEQ, 1JEY, 1Q2Z, 1RW2, 3RZ9

7520

22596

ENSG00000079246

ENSMUSG00000026187

P13010

P27641

NM_021141

NM_009533

NP_066964

NP_033559.2
NP_033559

Ku80 is a protein that, in humans, is encoded by the XRCC5 gene. Together, Ku70 and Ku80 make up the Ku heterodimer, which binds to DNA double-strand break ends and is required for the non-homologous end joining (NHEJ) pathway of DNA repair. It is also required for V(D)J recombination, which utilizes the NHEJ pathway to promote antigen diversity in the mammalian immune system.

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Wikipedia