L-leucine

Leucine

L-Leucine
L-Leucine at physiological pH
Names
IUPAC name Leucine
Other names 2-Amino-4-methylpentanoic acid
Identifiers
CAS Number	61-90-5 Y
3D model (Jmol)	Interactive image
ChEBI	CHEBI:57427 Y
ChemSpider	5880 Y
DrugBank	DB01746 Y
ECHA InfoCard	100.000.475
IUPHAR/BPS	3312
KEGG	D00030 Y
PubChem CID	6106
UNII	GMW67QNF9C Y
InChI InChI=1S/C6H13NO2/c1-4(2)3-5(7)6(8)9/h4-5H,3,7H2,1-2H3,(H,8,9)/t5-/m0/s1 Y Key: ROHFNLRQFUQHCH-YFKPBYRVSA-N Y InChI=1/C6H13NO2/c1-4(2)3-5(7)6(8)9/h4-5H,3,7H2,1-2H3,(H,8,9)/t5-/m0/s1 Key: ROHFNLRQFUQHCH-YFKPBYRVBU
SMILES CC(C)C[C@@H](C(=O)O)N
Properties
Chemical formula	C6H13NO2
Molar mass	131.18 g·mol−1
Acidity (pKa)	2.36 (carboxyl), 9.60 (amino)
Magnetic susceptibility (χ)	-84.9·10−6 cm3/mol
Supplementary data page
Structure and properties	Refractive index (n), Dielectric constant (εr), etc.
Thermodynamic data	Phase behaviour solid–liquid–gas
Spectral data	UV, IR, NMR, MS
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
N  (what is YN ?)
Infobox references

Leucine (abbreviated as Leu or L; encoded by the six codons UUA, UUG, CUU, CUC, CUA, and CUG) is an α-amino acid used in the biosynthesis of proteins. It contains an α-amino group (which is in the protonated −NH+
3 form under biological conditions), an α-carboxylic acid group (which is in the deprotonated −COO⁻ form under biological conditions), and an isobutyl side chain, classifying it as a nonpolar (at physiological pH) amino acid. It is essential in humans—meaning the body cannot synthesize it and thus must obtain from the diet.

Leucine is a major component of the subunits in ferritin, astacin, and other "buffer" proteins.

Leucine is used in the liver, adipose tissue, and muscle tissue. Adipose and muscle tissue use leucine in the formation of sterols. Combined leucine use in these two tissues is seven times greater than in the liver.

Leucine is rapidly taken up into the brain where astrocytes convert it to alpha-ketoisocaproate via transamination of alpha-ketoglutarate to glutamate. [reference: Yudoff, Mark. (Feb 01 2017) "Interactions in the Metabolism of Glutamate and the Branched-Chain Amino Acids and ketoacids in the CNS" Neurochem Res. 2017 January; 42(1): 10-18. doi:10.1007/s11064-016-2057-z. ]

Leucine is an essential amino acid in the diet of animals because they lack the complete enzyme pathway to synthesize it de novo from potential precursor compounds. Consequently, they must ingest it, usually as a component of proteins. Plants and microorganisms synthesize leucine from pyruvic acid with a series of enzymes:

Synthesis of the small, hydrophobic amino acid valine also includes the initial part of this pathway.