Leucyl-tRNA synthetase

LARS
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2WFD
Identifiers
Aliases	LARS, HSPC192, LARS1, LEURS, LEUS, LFIS, LRS, PIG44, RNTLS, hr025Cl, ILFS1, Leucyl-tRNA synthetase
External IDs	MGI: 1913808 HomoloGene: 7083 GeneCards: LARS
Gene location (Human) Chr. Chromosome 5 (human) Band No data available Start 146,113,038 bp End 146,182,660 bp
Gene location (Mouse) Chr. Chromosome 18 (mouse) Band No data available Start 42,202,350 bp End 42,262,122 bp
RNA expression pattern More reference expression data
Gene ontology Molecular function • aminoacyl-tRNA ligase activity • nucleotide binding • leucine-tRNA ligase activity • ligase activity • protein binding • ATP binding • aminoacyl-tRNA editing activity • valine-tRNA ligase activity • GTPase activator activity • glutamine-tRNA ligase activity Cellular component • cytosol • nuclear body • cytoplasm • lysosome • endoplasmic reticulum • endomembrane system • aminoacyl-tRNA synthetase multienzyme complex Biological process • regulation of translational fidelity • tRNA aminoacylation for protein translation • translation • leucyl-tRNA aminoacylation • valyl-tRNA aminoacylation • protein targeting to lysosome • regulation of cell size • negative regulation of autophagy • cellular response to amino acid starvation • positive regulation of GTPase activity • cellular response to amino acid stimulus • cellular response to leucine • positive regulation of TORC1 signaling • cellular response to leucine starvation • glutaminyl-tRNA aminoacylation Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	51520	107045
Ensembl	ENSG00000133706	ENSMUSG00000024493
UniProt	Q9P2J5	Q8BMJ2
RefSeq (mRNA)	NM_020117 NM_001317964 NM_001317965 NM_016460	NM_134137
RefSeq (protein)	NP_001304893 NP_001304894 NP_057544 NP_064502	NP_598898
Location (UCSC)	Chr 5: 146.11 – 146.18 Mb	Chr 5: 42.2 – 42.26 Mb
PubMed search

2WFD

51520

107045

ENSG00000133706

ENSMUSG00000024493

Q9P2J5

Q8BMJ2

NM_020117
NM_001317964
NM_001317965
NM_016460

NM_134137

NP_001304893
NP_001304894
NP_057544
NP_064502

NP_598898

Leucyl-tRNA synthetase, cytoplasmic is an enzyme that in humans is encoded by the LARS gene.

This gene encodes a cytosolic leucine-tRNA synthetase, a member of the class I aminoacyl-tRNA synthetase family. The encoded enzyme catalyzes the ATP-dependent ligation of L-leucine to tRNA(Leu). It is found in the cytoplasm as part of a multisynthetase complex and interacts with the arginine tRNA synthetase through its C-terminal domain. Alternatively spliced transcript variants of this gene have been found; however, their full-length nature is not known.

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