MKI67IP

NIFK
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2AFF
Identifiers
Aliases	NIFK, MKI67IP, Nopp34, nucleolar protein interacting with the FHA domain of MKI67
External IDs	MGI: 1915199 HomoloGene: 49862 GeneCards: NIFK
Gene ontology Molecular function • protein binding • RNA binding • nucleic acid binding Cellular component • cytoplasm • condensed nuclear chromosome • chromosome • nucleolus • nucleus • nucleoplasm Biological process • negative regulation of phosphatase activity • rRNA transcription • rRNA metabolic process • protein complex assembly Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	84365	67949
Ensembl	ENSG00000155438	ENSMUSG00000026377
UniProt	Q9BYG3	Q91VE6
RefSeq (mRNA)	NM_032390	NM_026472
RefSeq (protein)	NP_115766	NP_080748.3 NP_080748
Location (UCSC)	Chr 2: 121.73 – 121.74 Mb	Chr 1: 118.32 – 118.33 Mb
PubMed search

FHA Ki67 binding domain of hNIFK
the solution structure of the ki67fha/hnifk(226-269)3p complex
Identifiers
Symbol	hNIFK_binding
Pfam	PF12196
InterPro	IPR021043
Available protein structures: Pfam structures PDB RCSB PDB; PDBe; PDBj PDBsum structure summary

2AFF

84365

67949

ENSG00000155438

ENSMUSG00000026377

Q9BYG3

Q91VE6

NM_032390

NM_026472

NP_115766

NP_080748.3
NP_080748

MKI67 FHA domain-interacting nucleolar phosphoprotein is a protein that in humans is encoded by the MKI67IP gene.

MKI67 FHA domain-interacting nucleolar phosphoprotein contains an RNA recognition motif (RRM) near to the N-terminus and a FHA Ki67 binding domain near to the C-terminus. There are two conserved sequence motifs within the FHA Ki67 binding domain: TPVCTP and LERRKS, this domain binds to the forkhead-associated domain of human Ki67. High-affinity binding requires sequential phosphorylation by two kinases, CDK1 and GSK3, yielding pThr238, pThr234 and pSer230. This interaction is involved in cell cycle regulation.