Myf5

MYF5
Identifiers
Aliases	MYF5, bHLHc2, myogenic factor 5
External IDs	MGI: 97252 HomoloGene: 4085 GeneCards: MYF5
Gene ontology Molecular function • DNA binding • sequence-specific DNA binding • protein dimerization activity • transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding • RNA polymerase II core promoter proximal region sequence-specific DNA binding • E-box binding • protein binding • protein heterodimerization activity • transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding Cellular component • nucleoplasm • RNA polymerase II transcription factor complex • nucleus Biological process • somitogenesis • embryonic skeletal system morphogenesis • cell differentiation • regulation of transcription, DNA-templated • muscle organ morphogenesis • ossification • positive regulation of muscle cell differentiation • regulation of transcription from RNA polymerase II promoter • muscle cell fate commitment • muscle organ development • extracellular matrix organization • transcription from RNA polymerase II promoter • positive regulation of skeletal muscle fiber development • transcription, DNA-templated • regulation of cell-matrix adhesion • multicellular organism development • positive regulation of myoblast fusion • positive regulation of myoblast differentiation • muscle tissue morphogenesis • skeletal muscle cell differentiation • camera-type eye development • skeletal muscle tissue development • cartilage condensation • positive regulation of transcription from RNA polymerase II promoter Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	4617	17877
Ensembl	ENSG00000111049	ENSMUSG00000000435
UniProt	P13349	P24699
RefSeq (mRNA)	NM_005593	NM_008656
RefSeq (protein)	NP_005584	NP_032682.1 NP_032682
Location (UCSC)	Chr 12: 80.72 – 80.72 Mb	Chr 10: 107.48 – 107.49 Mb
PubMed search

4617

17877

ENSG00000111049

ENSMUSG00000000435

P13349

P24699

NM_005593

NM_008656

NP_005584

NP_032682.1
NP_032682

Myogenic factor 5 is a protein that in humans is encoded by the MYF5 gene. It is a protein with a key role in regulating muscle differentiation or myogenesis, specifically the development of skeletal muscle. Myf5 belongs to a family of proteins known as myogenic regulatory factors (MRFs). These bHLH (basic helix loop helix) transcription factors act sequentially in myogenic differentiation. MRF family members include Myf5, MyoD (Myf3), myogenin, and MRF4 (Myf6). This transcription factor is the earliest of all MRFs to be expressed in the embryo, where it is only markedly expressed for a few days (specifically around 8 days post-somite formation and lasting until day 14 post-somite in mice). It functions during that time to commit myogenic precursor cells to become skeletal muscle. In fact, its expression in proliferating myoblasts has led to its classification as a determination factor. Furthermore, Myf5 is a master regulator of muscle development, possessing the ability to induce a muscle phenotype upon its forced expression in fibroblastic cells.

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Wikipedia