NAIP (gene)

NAIP
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2VM5
Identifiers
Aliases	NAIP, BIRC1, NLRB1, psiNLR family, apoptosis inhibitory protein, NLR family apoptosis inhibitory protein
External IDs	MGI: 1298226 HomoloGene: 136092 GeneCards: NAIP
Gene ontology Molecular function • peptidase inhibitor activity • nucleotide binding • cysteine-type endopeptidase inhibitor activity • metal ion binding • ubiquitin-protein transferase activity • protein binding • ATP binding • cysteine-type endopeptidase inhibitor activity involved in apoptotic process Cellular component • perikaryon • neuronal cell body • basolateral plasma membrane • neuron projection • extracellular exosome • cytoplasm • nucleus Biological process • negative regulation of neuron apoptotic process • negative regulation of cysteine-type endopeptidase activity involved in apoptotic process • response to amino acid • negative regulation of peptidase activity • immune system process • negative regulation of apoptotic process • nervous system development • response to axon injury • innate immune response • inflammatory response • apoptotic process • protein ubiquitination • positive regulation of canonical Wnt signaling pathway • mitotic spindle assembly • inhibition of cysteine-type endopeptidase activity involved in apoptotic process Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	4671	17948
Ensembl	n/a	ENSMUSG00000078945
UniProt	Q13075	Q9QUK4
RefSeq (mRNA)	NM_004536 NM_022892	NM_001126182 NM_010872
RefSeq (protein)	NP_001333799 NP_004527 NP_075043	NP_001119654.1 NP_035002.2 NP_001119654 NP_035002
Location (UCSC)	Chr 5: 70.97 – 71.03 Mb	Chr 13: 100.14 – 100.2 Mb
PubMed search

2VM5

4671

17948

n/a

ENSMUSG00000078945

Q13075

Q9QUK4

NM_004536
NM_022892

NM_001126182
NM_010872

NP_001333799
NP_004527
NP_075043

NP_001119654.1
NP_035002.2
NP_001119654
NP_035002

Baculoviral IAP repeat-containing protein 1 is a protein that in humans is encoded by the NAIP gene.

This gene is part of a 500 kb inverted duplication on chromosome 5q13. This duplicated region contains at least four genes and repetitive elements which make it prone to rearrangements and deletions. The repetitiveness and complexity of the sequence have also caused difficulty in determining the organization of this genomic region. This copy of the gene is full length; additional copies with truncations and internal deletions are also present in this region of chromosome 5q13. It is thought that this gene is a modifier of spinal muscular atrophy caused by mutations in a neighboring gene, SMN1. The protein encoded by this gene contains regions of homology to two baculovirus inhibitor of apoptosis proteins, and it is able to suppress apoptosis induced by various signals. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.

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Wikipedia