RAD21

RAD21
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4PJU, 4PJW, 4PK7
Identifiers
Aliases	RAD21, CDLS4, HR21, HMCD1, NXP1, SCC1, hHR21, RAD21 cohesin complex component
External IDs	MGI: 108016 HomoloGene: 38161 GeneCards: RAD21
Gene ontology Molecular function • transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding • protein binding • chromatin binding • protein complex binding Cellular component • cytosol • membrane • cohesin complex • chromosome • nucleoplasm • condensed nuclear chromosome • nuclear chromosome • chromatin • chromosome, centromeric region • nucleus • nuclear cohesin complex Biological process • reciprocal meiotic recombination • DNA recombination • chromosome segregation • regulation of transcription from RNA polymerase II promoter • transcription from RNA polymerase II promoter • cellular response to DNA damage stimulus • cell division • double-strand break repair • cell cycle • protein localization to chromatin • DNA repair • positive regulation of transcription from RNA polymerase II promoter • apoptotic process • sister chromatid cohesion • positive regulation of sister chromatid cohesion • negative regulation of G2/M transition of mitotic cell cycle • negative regulation of mitotic metaphase/anaphase transition Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	5885	19357
Ensembl	ENSG00000164754	ENSMUSG00000022314
UniProt	O60216	Q61550
RefSeq (mRNA)	NM_006265	NM_009009
RefSeq (protein)	NP_006256	NP_033035.3 NP_033035
Location (UCSC)	Chr 8: 116.85 – 116.87 Mb	Chr 15: 51.96 – 51.99 Mb
PubMed search

4PJU, 4PJW, 4PK7

5885

19357

ENSG00000164754

ENSMUSG00000022314

O60216

Q61550

NM_006265

NM_009009

NP_006256

NP_033035.3
NP_033035

Double-strand-break repair protein rad21 homolog is a protein that in humans is encoded by the RAD21 gene.

The protein encoded by this gene is highly similar to the gene product of Schizosaccharomyces pombe rad21, a gene involved in the repair of DNA double-strand breaks, as well as in chromatid cohesion during mitosis. This protein is a nuclear phospho-protein, which becomes hyperphosphorylated in cell cycle M phase. The highly regulated association of this protein with mitotic chromatin specifically at the centromere region suggests its role in sister chromatid cohesion in mitotic cells.

RAD21 has been shown to interact with SMARCA5.

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Wikipedia