SMARCA5

SMARCA5
Identifiers
Aliases	SMARCA5, ISWI, SNF2H, WCRF135, hISWI, hSNF2H, SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5
External IDs	MGI: 1935129 HomoloGene: 55764 GeneCards: SMARCA5
Gene ontology Molecular function • nucleotide binding • helicase activity • histone binding • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • protein binding • nucleic acid binding • nucleosome binding • hydrolase activity • DNA binding • ATP binding • ATPase activity Cellular component • RSF complex • nuclear replication fork • nucleoplasm • condensed chromosome • nucleus • fibrillar center • NURF complex Biological process • positive regulation of gene expression, epigenetic • regulation of transcription from RNA polymerase II promoter • nucleosome positioning • CENP-A containing nucleosome assembly • ATP-dependent chromatin remodeling • DNA-templated transcription, initiation • nucleosome assembly • covalent chromatin modification • chromatin remodeling Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	8467	93762
Ensembl	ENSG00000153147	ENSMUSG00000031715
UniProt	O60264	Q91ZW3
RefSeq (mRNA)	NM_003601	NM_053124
RefSeq (protein)	NP_003592	NP_444354
Location (UCSC)	Chr 4: 143.51 – 143.56 Mb	Chr 8: 80.7 – 80.74 Mb
PubMed search

8467

93762

ENSG00000153147

ENSMUSG00000031715

O60264

Q91ZW3

NM_003601

NM_053124

NP_003592

NP_444354

SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 5 is a protein that in humans is encoded by the SMARCA5 gene.

The protein encoded by this gene is a member of the SWI/SNF family of proteins. Members of this family have helicase and ATPase activities and are thought to regulate transcription of certain genes by altering the chromatin structure around those genes. The protein encoded by this gene is a component of the chromatin remodeling and spacing factor RSF, a facilitator of the transcription of class II genes by RNA polymerase II. The encoded protein is similar in sequence to the Drosophila ISWI chromatin remodeling protein.

SMARCA5 has been shown to interact with RAD21,Histone deacetylase 2,POLE3,SATB1 and BAZ1A.

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Wikipedia