RASGRP3

RASGRP3
Identifiers
Aliases	RASGRP3, GRP3, RAS guanyl releasing protein 3
External IDs	MGI: 3028579 HomoloGene: 15019 GeneCards: RASGRP3
Genetically Related Diseases
systemic lupus erythematosus
Gene ontology Molecular function • calcium ion binding • guanyl-nucleotide exchange factor activity • GTPase activator activity • signal transducer activity • Ras GTPase binding • metal ion binding • kinase binding • protein binding • diacylglycerol binding • Ras guanyl-nucleotide exchange factor activity Cellular component • cytoplasm • plasma membrane • integral component of plasma membrane • perinuclear region of cytoplasm • guanyl-nucleotide exchange factor complex • intracellular Biological process • intracellular signal transduction • regulation of GTPase activity • small GTPase mediated signal transduction • MAPK cascade • positive regulation of GTPase activity • Ras protein signal transduction Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	25780	240168
Ensembl	ENSG00000152689	ENSMUSG00000071042
UniProt	Q8IV61	n/a
RefSeq (mRNA)	NM_001139488 NM_015376 NM_170672	NM_001166493 NM_207246
RefSeq (protein)	NP_001132960 NP_056191 NP_733772	n/a
Location (UCSC)	Chr 2: 33.44 – 33.56 Mb	Chr 17: 75.44 – 75.53 Mb
PubMed search

25780

240168

ENSG00000152689

ENSMUSG00000071042

Q8IV61

n/a

NM_001139488
NM_015376
NM_170672

NM_001166493
NM_207246

NP_001132960
NP_056191
NP_733772

n/a

Ras guanyl-releasing protein 3 is a protein that in humans is encoded by the RASGRP3 gene.

Members of the RAS (see HRAS; MIM 190020) subfamily of GTPases function in signal transduction as GTP/GDP-regulated switches that cycle between inactive GDP- and active GTP-bound states. Guanine nucleotide exchange factors (GEFs), such as RASGRP3, serve as RAS activators by promoting acquisition of GTP to maintain the active GTP-bound state and are the key link between cell surface receptors and RAS activation (Rebhun et al., 2000).

RASGRP3 has been shown to interact with PRKCD.

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Wikipedia